COSTI, Maria Paola
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 44.328
EU - Europa 21.217
AS - Asia 19.567
SA - Sud America 2.804
Continente sconosciuto - Info sul continente non disponibili 750
AF - Africa 446
OC - Oceania 57
Totale 89.169
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 43.298
SG - Singapore 5.764
IT - Italia 5.685
CN - Cina 5.590
GB - Regno Unito 5.579
DE - Germania 2.626
VN - Vietnam 2.255
BR - Brasile 2.134
HK - Hong Kong 1.911
SE - Svezia 1.854
FR - Francia 1.117
RU - Federazione Russa 876
BD - Bangladesh 869
FI - Finlandia 791
KR - Corea 694
UA - Ucraina 681
CA - Canada 585
IN - India 482
TR - Turchia 460
PL - Polonia 411
ID - Indonesia 308
BG - Bulgaria 276
AR - Argentina 247
JP - Giappone 217
NL - Olanda 212
IQ - Iraq 179
MX - Messico 179
BE - Belgio 167
ES - Italia 156
IE - Irlanda 147
ZA - Sudafrica 137
LT - Lituania 123
PK - Pakistan 107
CH - Svizzera 96
EC - Ecuador 90
AE - Emirati Arabi Uniti 89
MY - Malesia 76
CL - Cile 74
AT - Austria 72
VE - Venezuela 72
UZ - Uzbekistan 68
CO - Colombia 66
IR - Iran 61
SA - Arabia Saudita 61
PH - Filippine 58
MA - Marocco 57
CR - Costa Rica 50
CZ - Repubblica Ceca 49
PY - Paraguay 49
JO - Giordania 46
AU - Australia 44
JM - Giamaica 42
KE - Kenya 40
DZ - Algeria 39
EG - Egitto 39
PT - Portogallo 39
RO - Romania 36
TN - Tunisia 34
GT - Guatemala 29
HN - Honduras 29
UY - Uruguay 29
AZ - Azerbaigian 28
ET - Etiopia 26
KZ - Kazakistan 26
NP - Nepal 26
PE - Perù 26
TH - Thailandia 25
TW - Taiwan 25
GR - Grecia 24
LU - Lussemburgo 22
DK - Danimarca 21
EU - Europa 21
IL - Israele 20
NI - Nicaragua 20
DO - Repubblica Dominicana 19
AL - Albania 18
BY - Bielorussia 18
HU - Ungheria 18
RS - Serbia 17
BO - Bolivia 16
SV - El Salvador 16
NO - Norvegia 15
TT - Trinidad e Tobago 15
BH - Bahrain 13
EE - Estonia 13
LB - Libano 13
OM - Oman 13
SN - Senegal 13
NZ - Nuova Zelanda 12
KG - Kirghizistan 11
MD - Moldavia 11
PS - Palestinian Territory 11
BA - Bosnia-Erzegovina 10
BB - Barbados 10
QA - Qatar 10
SC - Seychelles 10
LV - Lettonia 9
PR - Porto Rico 9
GE - Georgia 8
NG - Nigeria 8
Totale 88.297
Salva come PNG Salva come JPEG
Città #
Ashburn 5.301
Southend 3.786
Santa Clara 3.615
Singapore 3.462
Fairfield 2.986
Houston 2.392
San Jose 2.140
Woodbridge 2.116
Chandler 2.082
Hong Kong 1.863
Hefei 1.788
Council Bluffs 1.519
Frankfurt am Main 1.258
Ann Arbor 1.253
Jacksonville 1.236
Seattle 1.193
Cambridge 1.155
Dearborn 1.137
Wilmington 1.075
Nyköping 1.005
Beijing 877
Modena 857
London 794
Los Angeles 722
Ho Chi Minh City 708
New York 697
Seoul 646
Chicago 526
Hanoi 519
Helsinki 511
The Dalles 446
Milan 397
Princeton 289
San Diego 280
Shanghai 272
Sofia 268
Lauterbourg 259
Moscow 259
Kraków 255
Buffalo 252
Munich 238
Eugene 229
São Paulo 223
Bologna 218
Jakarta 209
Boardman 197
Izmir 196
Dallas 189
Orem 184
Fremont 174
Rome 171
Redwood City 156
Tokyo 153
Columbus 151
Salt Lake City 143
Denver 138
Toronto 138
Dublin 134
Des Moines 131
Brussels 129
Atlanta 126
Warsaw 125
Bremen 123
Phoenix 117
Da Nang 116
Parma 107
Porto Alegre 96
Montreal 93
Ottawa 93
Brooklyn 92
Chennai 88
Guangzhou 88
Reggio Emilia 86
Naples 84
Tampa 79
Washington 78
Haiphong 77
Amsterdam 75
Elk Grove Village 74
Falls Church 68
Stockholm 66
Turku 66
Kent 65
Turin 64
Rio de Janeiro 63
Baghdad 62
Mexico City 59
Grafing 58
Johannesburg 58
Manchester 58
San Francisco 57
Tashkent 57
Belo Horizonte 55
Verona 55
Paris 54
Dong Ket 52
Poplar 51
Brasília 50
Dhaka 50
Nanjing 49
Totale 58.731
Salva come PNG Salva come JPEG
Nome #
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.240
STRUTTURA DEL CRISTALLO DEL COMPLESSO DI TIMIDILATO SINTETASI (TS) CON UN LIGANDO 859
TYDOCK PHARMA s.r.l. Spin Off dell'Università di Modena e Reggio Emilia che ha come fine l'attività di ricerca e sviluppo nel settore delle biotech farmaceutiche. 697
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 507
Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines 492
Metodo per la funzionalizzazione sito specifica di molecole proteiche 489
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 481
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells 477
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 473
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 472
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes 467
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 455
USO DI INIBITORI DELLA PTERIDINA REDUTTASI PER LA PREVENZIONE E/O IL TRATTAMENTO DI INFEZIONI PARASSITARIE 454
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. 454
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 444
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase 441
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase 440
New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines 438
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 435
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 432
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 430
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 429
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 427
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 419
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells 418
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 417
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines 417
Antibacterial agent discovery using thymidylate synthase biolibrary screening 415
Repurposing of drugs targeting yap-tead functions 412
Translational repression of thymidylate synthase by targeting its mRNA 412
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 411
A condensed thiadiazolo-pyrimidine as a new efficient fluorophore. Theoretical and experimental investigation of the electronic spectra and photophysics 408
Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology 406
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 404
Structure-based studies on species-specific inhibition of thymidylate synthase 399
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 399
Allosteric Inhibition of human Thymidylate Synthase. 397
Biochemistry: Anchors away 396
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 394
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 393
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 392
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment 392
Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides 391
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 388
Aprepitant as anticancer drug 387
Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides 385
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 383
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 380
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 378
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 378
Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins 378
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 375
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity 372
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 371
Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors 370
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 370
Thymidylate synthase structure, function and implication in drug discovery 367
A proteomic approach to investigate the mechanism of action of anticancer peptides 367
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 364
Crystal Structure of histidine-tagged human thymidylate synthase 364
Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer 362
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 361
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 360
Maxwell A: F1000Prime Recommendation of Evaluation [Neres J et al., ACS Chem Biol 2014]. In F1000Prime, 09 Jan 2015; DOI: 10.3410/f.725248139.793502885. F1000Prime.com/725248139#eval793502885 359
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development 357
Theoretical study of electronic spectra and photophysics of uracil derivatives. 355
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells 352
Current and Future Chemotherapy for Chagas Disease 352
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase 348
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 348
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections 348
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 348
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 348
ANTICANCER DRUGS 345
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 345
TSI INDUCES APOPTOSIS WITH A P53 INDIPENDENT PATHWAY IN MELANOMA CELL LINES AND IN NORMAL HUMAN MELANOCITES 345
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 344
Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents 339
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 339
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase 339
Biochemical effects of riluzole on Leishmania parasites 338
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 337
Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer 337
CYCLIZATION REACTIONS OF 1,3-DIBROMOPROPAN-2-OL, 2,3-DIBROMOPROPAN-1-OL AND 1-BROMOMETHYLOXIRANE WITH 6-AMINO-2,3-DIHYDRO-2-THIOXO-4(1H)-PYRIMIDINONE 335
QUINOXALINE DERIVATIVES AS ANTITUBERCULOSIS AGENTS 334
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 334
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 332
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 331
Homodimeric Enzymes as Drug Targets 330
Thymidylate synthase inhibition: A structure-based rationale for drug design 326
Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”. 326
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 326
MITO-group Multicenter italian trials in ovarian cancer and gynecological malignancies Borad of directors-translational research group 326
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 325
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 325
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 325
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 324
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors 324
Targeting the trypanosomatidic enzymes pteridine reductase and dihydrofolate reductase. 323
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 321
Totale 39.975
Salva come PNG Salva come JPEG
Categoria #
all - tutte 322.555
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 322.555
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20224.406 0 0 0 303 243 554 249 355 621 393 1.054 634
2022/20236.286 753 755 420 606 640 893 189 601 738 102 307 282
2023/20245.651 196 276 324 410 1.984 485 280 486 138 133 384 555
2024/202514.165 599 196 431 935 2.637 1.853 975 805 1.426 644 1.699 1.965
2025/202625.808 1.687 1.175 2.028 2.919 3.786 1.807 3.241 1.301 2.414 2.465 1.685 1.300
2026/20277.033 763 1.771 2.134 2.365 0 0 0 0 0 0 0 0
Totale 89.169