COSTI, Maria Paola
 Distribuzione geografica
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Continente #
NA - Nord America 38.507
EU - Europa 20.838
AS - Asia 19.440
SA - Sud America 2.747
AF - Africa 427
OC - Oceania 56
Continente sconosciuto - Info sul continente non disponibili 29
Totale 82.044
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Nazione #
US - Stati Uniti d'America 37.747
SG - Singapore 5.738
CN - Cina 5.566
GB - Regno Unito 5.547
IT - Italia 5.396
DE - Germania 2.620
VN - Vietnam 2.252
BR - Brasile 2.102
HK - Hong Kong 1.896
SE - Svezia 1.853
FR - Francia 1.108
RU - Federazione Russa 870
BD - Bangladesh 844
FI - Finlandia 791
KR - Corea 694
UA - Ucraina 679
IN - India 481
TR - Turchia 460
CA - Canada 446
PL - Polonia 411
ID - Indonesia 304
BG - Bulgaria 274
AR - Argentina 243
NL - Olanda 209
JP - Giappone 204
IQ - Iraq 179
MX - Messico 173
BE - Belgio 167
ES - Italia 152
IE - Irlanda 146
ZA - Sudafrica 134
LT - Lituania 114
PK - Pakistan 106
CH - Svizzera 95
AE - Emirati Arabi Uniti 89
EC - Ecuador 85
MY - Malesia 75
AT - Austria 72
CL - Cile 71
UZ - Uzbekistan 67
VE - Venezuela 67
CO - Colombia 62
IR - Iran 61
SA - Arabia Saudita 60
MA - Marocco 57
PH - Filippine 52
CZ - Repubblica Ceca 49
PY - Paraguay 49
JO - Giordania 46
AU - Australia 43
KE - Kenya 40
DZ - Algeria 39
PT - Portogallo 39
EG - Egitto 38
RO - Romania 35
TN - Tunisia 34
AZ - Azerbaigian 27
UY - Uruguay 27
ET - Etiopia 26
KZ - Kazakistan 26
NP - Nepal 26
JM - Giamaica 25
PE - Perù 25
TW - Taiwan 25
GR - Grecia 23
TH - Thailandia 23
LU - Lussemburgo 22
CR - Costa Rica 21
DK - Danimarca 21
EU - Europa 21
DO - Repubblica Dominicana 19
BY - Bielorussia 18
HU - Ungheria 18
AL - Albania 17
IL - Israele 17
BO - Bolivia 16
NO - Norvegia 15
BH - Bahrain 13
LB - Libano 13
OM - Oman 13
RS - Serbia 13
SN - Senegal 13
GT - Guatemala 12
NZ - Nuova Zelanda 12
HN - Honduras 11
KG - Kirghizistan 11
PS - Palestinian Territory 11
MD - Moldavia 10
NI - Nicaragua 10
QA - Qatar 10
BA - Bosnia-Erzegovina 9
LV - Lettonia 9
EE - Estonia 8
GE - Georgia 8
NG - Nigeria 8
PA - Panama 8
SK - Slovacchia (Repubblica Slovacca) 8
SV - El Salvador 7
TT - Trinidad e Tobago 7
AM - Armenia 6
Totale 81.919
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Città #
Ashburn 3.805
Southend 3.786
Santa Clara 3.525
Singapore 3.447
Fairfield 2.985
Houston 2.383
Woodbridge 2.116
Chandler 2.082
Hong Kong 1.850
Hefei 1.788
San Jose 1.599
Frankfurt am Main 1.258
Ann Arbor 1.253
Jacksonville 1.235
Seattle 1.175
Cambridge 1.141
Dearborn 1.137
Wilmington 1.069
Nyköping 1.005
Beijing 871
Modena 845
London 793
Ho Chi Minh City 707
Council Bluffs 675
Los Angeles 669
Seoul 646
New York 618
Hanoi 517
Helsinki 511
The Dalles 440
Chicago 433
Milan 347
Princeton 287
San Diego 278
Sofia 268
Shanghai 264
Lauterbourg 259
Moscow 259
Kraków 255
Munich 238
Eugene 229
Buffalo 221
Jakarta 209
Bologna 206
São Paulo 200
Izmir 196
Boardman 183
Orem 177
Fremont 174
Redwood City 156
Rome 151
Dallas 141
Tokyo 141
Salt Lake City 137
Dublin 133
Brussels 129
Des Moines 129
Warsaw 124
Bremen 123
Da Nang 116
Parma 104
Porto Alegre 96
Atlanta 94
Denver 93
Ottawa 90
Chennai 88
Guangzhou 88
Phoenix 85
Reggio Emilia 83
Toronto 81
Brooklyn 79
Columbus 78
Haiphong 77
Tampa 77
Montreal 76
Amsterdam 74
Elk Grove Village 74
Falls Church 67
Naples 67
Stockholm 66
Turku 66
Kent 64
Baghdad 62
Rio de Janeiro 62
Grafing 58
Johannesburg 58
Mexico City 58
Manchester 57
Tashkent 57
Turin 57
Belo Horizonte 55
Verona 55
Dong Ket 52
Paris 51
Poplar 51
Dhaka 49
Nanjing 49
Brasília 47
Norwalk 45
San Francisco 45
Totale 54.829
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Nome #
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.223
STRUTTURA DEL CRISTALLO DEL COMPLESSO DI TIMIDILATO SINTETASI (TS) CON UN LIGANDO 831
TYDOCK PHARMA s.r.l. Spin Off dell'Università di Modena e Reggio Emilia che ha come fine l'attività di ricerca e sviluppo nel settore delle biotech farmaceutiche. 674
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 490
Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines 475
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 464
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 458
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells 458
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 453
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. 445
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes 440
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 437
Metodo per la funzionalizzazione sito specifica di molecole proteiche 433
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 430
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase 429
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase 428
New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines 425
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 420
USO DI INIBITORI DELLA PTERIDINA REDUTTASI PER LA PREVENZIONE E/O IL TRATTAMENTO DI INFEZIONI PARASSITARIE 417
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 412
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 410
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 408
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells 402
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 400
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 400
Translational repression of thymidylate synthase by targeting its mRNA 400
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 398
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines 397
Antibacterial agent discovery using thymidylate synthase biolibrary screening 397
Repurposing of drugs targeting yap-tead functions 394
A condensed thiadiazolo-pyrimidine as a new efficient fluorophore. Theoretical and experimental investigation of the electronic spectra and photophysics 393
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 388
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 388
Biochemistry: Anchors away 385
Structure-based studies on species-specific inhibition of thymidylate synthase 379
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 375
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 372
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 371
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 371
Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides 370
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 365
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 361
Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins 361
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 360
Thymidylate synthase structure, function and implication in drug discovery 359
Allosteric Inhibition of human Thymidylate Synthase. 359
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 356
Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors 356
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 356
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment 356
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 351
Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer 349
Maxwell A: F1000Prime Recommendation of Evaluation [Neres J et al., ACS Chem Biol 2014]. In F1000Prime, 09 Jan 2015; DOI: 10.3410/f.725248139.793502885. F1000Prime.com/725248139#eval793502885 347
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity 346
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 345
A proteomic approach to investigate the mechanism of action of anticancer peptides 343
Crystal Structure of histidine-tagged human thymidylate synthase 343
Current and Future Chemotherapy for Chagas Disease 343
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 342
Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides 342
Theoretical study of electronic spectra and photophysics of uracil derivatives. 339
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 338
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 338
Aprepitant as anticancer drug 335
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development 334
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections 333
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 331
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 330
ANTICANCER DRUGS 329
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 328
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 326
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 325
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 324
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 323
Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer 323
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase 323
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells 322
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 319
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 318
Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents 316
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against β-lactamase 316
Homodimeric Enzymes as Drug Targets 316
CYCLIZATION REACTIONS OF 1,3-DIBROMOPROPAN-2-OL, 2,3-DIBROMOPROPAN-1-OL AND 1-BROMOMETHYLOXIRANE WITH 6-AMINO-2,3-DIHYDRO-2-THIOXO-4(1H)-PYRIMIDINONE 315
Biochemical effects of riluzole on Leishmania parasites 315
Thymidylate synthase inhibition: A structure-based rationale for drug design 313
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors 313
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 312
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 312
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 311
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 311
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 310
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 310
MITO-group Multicenter italian trials in ovarian cancer and gynecological malignancies Borad of directors-translational research group 306
Theoretical analysis of the addition of hydroxylamine to uracil and 5-fluorouracil as a model for the Thymidylate synthase reaction 304
Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”. 304
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth 301
Permeation through the cell membrane of a boron-based β-lactamase inhibitor. 300
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case 298
Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity 298
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 296
Totale 37.795
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Categoria #
all - tutte 298.292
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 298.292
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20225.516 246 534 330 303 243 554 249 355 621 393 1.054 634
2022/20236.286 753 755 420 606 640 893 189 601 738 102 307 282
2023/20245.651 196 276 324 410 1.984 485 280 486 138 133 384 555
2024/202514.165 599 196 431 935 2.637 1.853 975 805 1.426 644 1.699 1.965
2025/202625.808 1.687 1.175 2.028 2.919 3.786 1.807 3.241 1.301 2.414 2.465 1.685 1.300
2026/2027621 621 0 0 0 0 0 0 0 0 0 0 0
Totale 82.757