COSTI, Maria Paola
 Distribuzione geografica
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Continente #
NA - Nord America 36.754
EU - Europa 20.374
AS - Asia 18.790
SA - Sud America 2.747
AF - Africa 432
OC - Oceania 55
Continente sconosciuto - Info sul continente non disponibili 28
Totale 79.180
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Nazione #
US - Stati Uniti d'America 36.131
SG - Singapore 5.718
GB - Regno Unito 5.567
CN - Cina 5.546
IT - Italia 4.896
DE - Germania 2.634
VN - Vietnam 2.264
BR - Brasile 2.110
HK - Hong Kong 1.904
SE - Svezia 1.865
FR - Francia 1.104
RU - Federazione Russa 876
FI - Finlandia 793
KR - Corea 702
UA - Ucraina 684
IN - India 483
TR - Turchia 460
PL - Polonia 411
CA - Canada 335
ID - Indonesia 302
BG - Bulgaria 275
AR - Argentina 242
BD - Bangladesh 216
NL - Olanda 208
JP - Giappone 198
IQ - Iraq 179
MX - Messico 175
BE - Belgio 167
ES - Italia 149
IE - Irlanda 147
ZA - Sudafrica 136
LT - Lituania 113
PK - Pakistan 106
CH - Svizzera 95
AE - Emirati Arabi Uniti 89
EC - Ecuador 84
AT - Austria 72
CL - Cile 71
MY - Malesia 71
UZ - Uzbekistan 67
VE - Venezuela 65
IR - Iran 61
SA - Arabia Saudita 60
CO - Colombia 59
MA - Marocco 57
PH - Filippine 52
PY - Paraguay 49
CZ - Repubblica Ceca 48
JO - Giordania 46
AU - Australia 42
DZ - Algeria 41
KE - Kenya 40
EG - Egitto 39
PT - Portogallo 37
RO - Romania 34
TN - Tunisia 34
AZ - Azerbaigian 27
NP - Nepal 27
UY - Uruguay 27
ET - Etiopia 26
KZ - Kazakistan 26
PE - Perù 24
TW - Taiwan 24
LU - Lussemburgo 22
TH - Thailandia 22
DK - Danimarca 21
EU - Europa 21
DO - Repubblica Dominicana 20
BY - Bielorussia 18
AL - Albania 17
GR - Grecia 17
HU - Ungheria 17
IL - Israele 17
BO - Bolivia 16
JM - Giamaica 16
CR - Costa Rica 15
OM - Oman 14
BH - Bahrain 13
LB - Libano 13
RS - Serbia 13
SN - Senegal 13
NO - Norvegia 12
NZ - Nuova Zelanda 12
KG - Kirghizistan 11
PS - Palestinian Territory 11
HN - Honduras 10
MD - Moldavia 10
QA - Qatar 10
GT - Guatemala 9
LV - Lettonia 9
NI - Nicaragua 9
EE - Estonia 8
GE - Georgia 8
NG - Nigeria 8
PA - Panama 8
SK - Slovacchia (Repubblica Slovacca) 8
BA - Bosnia-Erzegovina 7
AM - Armenia 6
GA - Gabon 6
LI - Liechtenstein 6
Totale 79.063
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Città #
Southend 3.800
Ashburn 3.517
Santa Clara 3.472
Singapore 3.443
Fairfield 2.984
Houston 2.380
Woodbridge 2.115
Chandler 2.090
Hong Kong 1.859
Hefei 1.807
San Jose 1.405
Frankfurt am Main 1.266
Ann Arbor 1.257
Jacksonville 1.242
Seattle 1.167
Dearborn 1.144
Cambridge 1.115
Wilmington 1.071
Nyköping 1.012
Beijing 858
Modena 837
London 794
Ho Chi Minh City 710
Seoul 654
Los Angeles 595
New York 527
Hanoi 521
Helsinki 512
Council Bluffs 479
The Dalles 444
Chicago 420
Princeton 289
San Diego 277
Milan 270
Sofia 269
Shanghai 265
Lauterbourg 261
Moscow 261
Kraków 255
Munich 238
Eugene 230
Jakarta 209
São Paulo 201
Izmir 196
Bologna 185
Buffalo 178
Fremont 175
Orem 173
Boardman 164
Redwood City 154
Salt Lake City 136
Tokyo 136
Dublin 134
Brussels 129
Des Moines 129
Warsaw 124
Bremen 123
Rome 123
Da Nang 117
Dallas 108
Parma 101
Porto Alegre 95
Ottawa 89
Chennai 88
Denver 88
Guangzhou 87
Atlanta 82
Phoenix 79
Reggio Emilia 78
Columbus 76
Haiphong 76
Tampa 76
Amsterdam 75
Elk Grove Village 73
Brooklyn 72
Falls Church 67
Stockholm 66
Turku 66
Kent 65
Montreal 64
Baghdad 62
Toronto 62
Rio de Janeiro 61
Johannesburg 60
Mexico City 60
Grafing 58
Manchester 57
Milwaukee 57
Tashkent 57
Belo Horizonte 55
Poplar 53
Verona 53
Dong Ket 52
Naples 51
Paris 51
Dhaka 49
Nanjing 49
Turin 49
Brasília 48
Norwalk 45
Totale 53.658
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Nome #
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.197
STRUTTURA DEL CRISTALLO DEL COMPLESSO DI TIMIDILATO SINTETASI (TS) CON UN LIGANDO 816
TYDOCK PHARMA s.r.l. Spin Off dell'Università di Modena e Reggio Emilia che ha come fine l'attività di ricerca e sviluppo nel settore delle biotech farmaceutiche. 645
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 481
Spermidine/spermine N1-acetyltranferasemodulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistanthuman ovarian cancer cell lines 456
Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells 450
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 446
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. 443
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 440
Metodo per la funzionalizzazione sito specifica di molecole proteiche 427
2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes 424
Virtual Screening and X-ray Crystallography Identify Non-Substrate Analog Inhibitors of Flavin-Dependent Thymidylate Synthase 423
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 422
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase 414
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1 408
New thymidylate synthase inhibitors induce apoptosis in melanoma cell lines 407
USO DI INIBITORI DELLA PTERIDINA REDUTTASI PER LA PREVENZIONE E/O IL TRATTAMENTO DI INFEZIONI PARASSITARIE 406
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 401
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform 399
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 398
Internalization and stability of a thymidylate synthase peptide inhibitor in ovarian cancer cells 398
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 397
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 393
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines 390
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 387
Biochemistry: Anchors away 383
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 382
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 380
Antibacterial agent discovery using thymidylate synthase biolibrary screening 377
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 373
Structure-based studies on species-specific inhibition of thymidylate synthase 372
Repurposing of drugs targeting yap-tead functions 371
A condensed thiadiazolo-pyrimidine as a new efficient fluorophore. Theoretical and experimental investigation of the electronic spectra and photophysics 369
Alanine Mutants of the Interface Residues of Human Thymidylate Synthase Decode Key Features of the Binding Mode of Allosteric Anticancer Peptides 363
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 362
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 362
Translational repression of thymidylate synthase by targeting its mRNA 362
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 361
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 360
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 358
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 356
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 352
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 351
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 348
Excited-state intramolecular proton transfer in a bioactive flavonoid provides fluorescence observables for recognizing its engagement with target proteins 347
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 344
The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment 344
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 343
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 341
A proteomic approach to investigate the mechanism of action of anticancer peptides 340
Allosteric Inhibition of human Thymidylate Synthase. 340
Dimer-monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer 339
ACS Medicinal Chemistry Letters. member of the Editorial Board 339
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 339
Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors 338
Proteomic Approach to the Detection of the Mechanism of Action of Anticancer Peptides 338
Crystal Structure of histidine-tagged human thymidylate synthase 335
Aprepitant as anticancer drug 332
Current and Future Chemotherapy for Chagas Disease 331
Maxwell A: F1000Prime Recommendation of Evaluation [Neres J et al., ACS Chem Biol 2014]. In F1000Prime, 09 Jan 2015; DOI: 10.3410/f.725248139.793502885. F1000Prime.com/725248139#eval793502885 325
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 323
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections 322
ANTICANCER DRUGS 321
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 321
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 318
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors 318
Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells 317
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 316
Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity 315
Theoretical study of electronic spectra and photophysics of uracil derivatives. 314
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 314
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 313
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development 312
Hotspots in an obligate homodimeric anticancer target. structural and functional effects of interfacial mutations in human thymidylate synthase 312
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 310
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 310
CYCLIZATION REACTIONS OF 1,3-DIBROMOPROPAN-2-OL, 2,3-DIBROMOPROPAN-1-OL AND 1-BROMOMETHYLOXIRANE WITH 6-AMINO-2,3-DIHYDRO-2-THIOXO-4(1H)-PYRIMIDINONE 309
Pharmacological and toxicological evaluation of a new series of thymidylate synthase inhibitors as anticancer agents 309
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 309
Thymidylate synthase structure, function and implication in drug discovery 309
Biochemical effects of riluzole on Leishmania parasites 309
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors 306
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 306
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 306
Thymidylate synthase inhibition: A structure-based rationale for drug design 304
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 304
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 304
Homodimeric Enzymes as Drug Targets 301
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 298
MITO-group Multicenter italian trials in ovarian cancer and gynecological malignancies Borad of directors-translational research group 296
Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer-US8916679 “B2 - Granted patent as second publication”. 294
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 293
QUINOXALINE DERIVATIVES AS ANTITUBERCULOSIS AGENTS 292
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus 292
Comparing Drug Images and Repurposing Drugs with BioGPS and FLAPdock: The Thymidylate Synthase Case 291
Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth 290
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 290
Protein-protein interaction inhibitors: case studies on Small Molecules and Natural Compounds. 289
Theoretical analysis of the addition of hydroxylamine to uracil and 5-fluorouracil as a model for the Thymidylate synthase reaction 289
Permeation through the cell membrane of a boron-based β-lactamase inhibitor. 288
Totale 36.459
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Categoria #
all - tutte 280.663
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 280.663
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021986 0 0 0 0 0 0 0 0 0 0 571 415
2021/20225.532 246 536 330 303 243 554 249 356 626 393 1.058 638
2022/20236.329 759 759 421 608 644 897 190 604 753 103 308 283
2023/20245.689 202 278 326 412 1.996 486 280 492 138 133 387 559
2024/202514.297 602 197 432 947 2.670 1.880 988 807 1.437 649 1.712 1.976
2025/202623.255 1.699 1.183 2.043 2.935 3.804 1.812 3.268 1.311 2.424 2.482 294 0
Totale 79.902