COSTANTINO, Luca
 Distribuzione geografica
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Continente #
NA - Nord America 22.317
EU - Europa 8.998
AS - Asia 8.810
SA - Sud America 1.218
AF - Africa 222
OC - Oceania 31
Continente sconosciuto - Info sul continente non disponibili 12
Totale 41.608
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Nazione #
US - Stati Uniti d'America 22.056
GB - Regno Unito 3.110
SG - Singapore 2.625
CN - Cina 2.536
IT - Italia 1.498
SE - Svezia 1.044
VN - Vietnam 1.017
HK - Hong Kong 1.006
BR - Brasile 952
DE - Germania 816
UA - Ucraina 494
RU - Federazione Russa 446
FI - Finlandia 424
FR - Francia 402
TR - Turchia 393
KR - Corea 297
IN - India 248
BG - Bulgaria 177
CA - Canada 132
NL - Olanda 122
BD - Bangladesh 101
AR - Argentina 89
JP - Giappone 85
ID - Indonesia 79
MX - Messico 78
IQ - Iraq 77
ZA - Sudafrica 66
PL - Polonia 62
ES - Italia 59
IE - Irlanda 59
PK - Pakistan 48
BE - Belgio 47
EC - Ecuador 42
CH - Svizzera 39
AE - Emirati Arabi Uniti 36
CL - Cile 34
MA - Marocco 31
PH - Filippine 29
LT - Lituania 28
AU - Australia 27
RO - Romania 27
PY - Paraguay 25
CO - Colombia 24
EG - Egitto 24
VE - Venezuela 23
AT - Austria 21
SA - Arabia Saudita 21
IR - Iran 20
KE - Kenya 20
TW - Taiwan 20
DZ - Algeria 19
JO - Giordania 19
PT - Portogallo 18
AZ - Azerbaigian 17
MY - Malesia 17
MD - Moldavia 15
TH - Thailandia 15
UZ - Uzbekistan 15
CZ - Repubblica Ceca 14
NP - Nepal 14
PE - Perù 14
TN - Tunisia 13
BY - Bielorussia 11
EU - Europa 11
UY - Uruguay 10
DK - Danimarca 9
GR - Grecia 9
SN - Senegal 9
IL - Israele 8
NO - Norvegia 8
DO - Repubblica Dominicana 7
KZ - Kazakistan 7
LB - Libano 7
LK - Sri Lanka 7
RS - Serbia 7
AO - Angola 6
BH - Bahrain 6
EE - Estonia 6
ET - Etiopia 6
GT - Guatemala 6
JM - Giamaica 6
QA - Qatar 6
CI - Costa d'Avorio 5
CR - Costa Rica 5
KG - Kirghizistan 5
NG - Nigeria 5
NI - Nicaragua 5
AL - Albania 4
BO - Bolivia 4
BZ - Belize 4
GE - Georgia 4
HR - Croazia 4
HU - Ungheria 4
KW - Kuwait 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
OM - Oman 4
PA - Panama 4
PS - Palestinian Territory 4
SK - Slovacchia (Repubblica Slovacca) 4
Totale 41.555
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Città #
Southend 2.220
Fairfield 2.118
Ashburn 1.856
Santa Clara 1.842
Singapore 1.612
Woodbridge 1.451
Chandler 1.119
Houston 1.026
Hong Kong 990
Seattle 943
Jacksonville 941
Hefei 858
Wilmington 819
Ann Arbor 788
Dearborn 751
Cambridge 742
Chicago 625
San Jose 585
Nyköping 559
Beijing 431
Los Angeles 431
London 408
Ho Chi Minh City 319
Salt Lake City 264
Helsinki 261
The Dalles 256
Council Bluffs 251
Hanoi 247
Seoul 246
Modena 225
Izmir 207
San Diego 206
Princeton 198
Sofia 170
Eugene 166
Frankfurt am Main 145
New York 143
Dallas 136
Lauterbourg 136
Milan 127
Bremen 125
Moscow 124
Buffalo 123
Shanghai 105
Elk Grove Village 103
Redwood City 98
Tampa 91
Orem 78
São Paulo 75
Des Moines 69
Tokyo 69
Rome 59
Dublin 56
Lancaster 55
Munich 55
Sterling 53
Bologna 48
Columbus 48
Fremont 48
Guangzhou 48
Da Nang 43
Haiphong 43
Phoenix 43
Chennai 42
Atlanta 39
Verona 38
Boardman 37
Nanjing 37
Miami 36
Jakarta 34
Amsterdam 33
Denver 32
Mexico City 32
Parma 31
Norwalk 30
Rio de Janeiro 30
Brussels 29
Detroit 29
Montreal 29
Toronto 28
Baghdad 27
Jinan 27
Kunming 27
Mumbai 27
Philadelphia 27
Brooklyn 26
Napoli 26
Belo Horizonte 24
Dulles 24
San Francisco 24
Naples 23
New Delhi 23
Paris 23
Stockholm 23
Marseille 22
Warsaw 22
Cape Town 20
Biên Hòa 19
Brasília 19
Groningen 19
Totale 29.515
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Nome #
Targeting the Central Nervous System: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123 465
1-Benzopyran-4-one antioxidants as aldose reductase inhibitors 457
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 440
PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid 432
7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study 418
Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures 412
Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution 408
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant 407
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 398
Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution 397
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 397
Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors 385
Laboratorio di Preparazione Estrattiva e Sintetica dei Farmaci 380
Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier 379
Synthesis and biological evaluation of new imidazole, pyrimidine, and purine derivatives and analogs as inhibitors of xanthine oxidase 367
A rational approach to the design of flavones as xanthine oxidase inhibitors 362
2′-Deoxyuridine 5′-Monophosphate Substrate Displacement in Thymidylate Synthase through 6-Hydroxy-2H-naphtho[1,8-bc]furan-2-one Derivatives 362
Polymeric nanoparticles for the drug delivery to the central nervous system 359
Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs 352
Privileged structures as leads in medicinal chemistry 350
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 341
Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH. 340
A model of the interaction of substrates and inhibitors with xanthine oxidase 332
Current and Future Chemotherapy for Chagas Disease 331
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 327
Is there a clinical future for polymeric nanoparticles as brain targeting drug delivery agents? 326
Surface engineering of Solid Lipid Nanoparticle assemblies by methyl α-d-mannopyranoside for the active targeting to macrophages in anti-tuberculosis inhalation therapy 326
STAT3 as Target for cancer drug discovery 325
Challenges in the design of clinically useful brain-targeted drug nanocarriers 323
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles 323
ANTICANCER DRUGS 321
ANTIINFLAMMATORY ACTIVITY OF NEWLY SYNTHESIZED 2,6-BIS-(1,1-DIMETHYLETHYL)PHENOL DERIVATIVES 320
Synthesis and description of chalcone-like compounds, inhibitors of aldose reductase 320
Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase 318
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To InhibitTrypanosoma bruceiPteridine Reductase in Support of Early-Stage Drug Discovery 318
Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors 315
Anti-TB inhalation therapy: Design of mannose-based functionalised Solid Lipid Microparticles for an active targeting to alveolar macrophages 314
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds 313
Development of flavonoids derivatives as leads against Leishmaniasis and Trypanosomiasis-invited lecture 310
Binding of 1-benzopyran-4-one derivatives to aldose reductase: A free energy perturbation study 304
Colloidal systems for CNS drug delivery 297
Designed multiple ligands: basic research vs clinical outcomes 297
New aldose reductase inhibitors as potential agents for the prevention of long-term diabetic complications 295
Applicazione delle tecniche microscopiche, spettroscopiche e calorimetriche nella caratterizzazione di nanoparticelle funzionalizzate 293
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent 290
Structure-based design of an inhibitor modeled at the substrate active site of aldose reductase 283
Synthesis and activity of a new series of chalcones as aldose reductase inhibitors 282
Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives 282
Glycopeptide-decorated nanoparticles as drug carriers for CNS: effects of surface coverage and carbohydrate type 280
Structural bases for the inhibition of aldose reductase by phenolic compounds 276
Soft docking and multiple receptor conformations in virtual screening. 274
Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches 273
A series of diarylsubstituted oximes as potential substrates for new aldose reductase inhibitors 272
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 272
Isolation and Pharmacological Activities of the Tecoma stans Alkaloids 270
Magnetic and Optical Bistability in Tetrairon(III) Single Molecule Magnets Functionalized with Azobenzene Groups 270
Novel engineered lipid-based nanoparticles for pulmonary tuberculosis inhalation therapy 270
Peptide-derivatized biodegradable nanoparticles able to cross the blood brain barrier 269
Iron acquisition pathways as targets for antitubercular drugs 269
Ghrelin receptor modulators: a patent review (2011-2014) 269
Folate: Relevance of Chemical and Microbial Production 267
Ghrelin receptor modulators and their therapeutic potential 267
Cell internalization study of hybrid chitosan-heparin-PLGA nanocarriers on Caco-2 cells 266
Small-angle neutron scattering characterization of liposomes for anti-tuberculosis inhaled therapy. 265
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 262
Binding of beta-carbolines and related agents at serotonin (5-HT-2 and 5-HT-1A), dopamine (D-2) and benzodiazepine receptors 262
ANTHOCYANIDINES AS INHIBITORS OF XANTHINE-OXIDASE 259
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da GLYCYRRHIZA GLABRA L. 259
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment? 259
Engineered polylactide-co-glycolide(PLGA) Np as drug delivery systems for the Central Nervous System 256
Synthesis and Aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones. 254
Nitrophenyl derivatives as Aldose Reductase inhibitors 252
Physico-chemical properties of anthocyanidins. Part 1. Theoretical evaluation of the stability of the neutral and anionic tautomeric forms 250
Discovery of new inhibitors of aldose reductase from molecular docking and database screening 250
Activité Antilipoperoxydante d'Extraits Polyphenoliques de Ribes Nigrum L. 246
COMPOSTI AD ATTIVITÀ ANTIPARASSITARIA 246
Pharmacological approaches to the treatment of diabetic complications 245
Solvent effects on the tautomerism of apigeninidin 244
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 244
Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? 243
Aerodynamic performance of lipid-based nanocarrier functionalized by novel mannose derivatives for Rifampicin intramacrophagic delivery 242
Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin 241
Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders 240
Drugs/lamellae interface influences the inner structure of double-loaded liposomes for inhaled anti-TB therapy: An in-depth small-angle neutron scattering investigation 240
Nanoparticelle per il direzionamento cerebrale di farmaci 238
SURFACE ENGINEERING OF SOLID LIPID NANOASSEMBLIES FOR INHALED INTRAMACROPHAGIC ANTI-TB THERAPY 236
Interaction of nanoparticles with immunocompetent cells: nanosafety considerations. 232
Peptide-decorated nanoparticles as carriers for drug delivery to CNS 230
Surface decorated nanoparticles as drug delivery agents to the brain 230
Modified PLGA Nanoparticles as drug carriers for CNS delivery 229
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 229
Nanoparticles for drug delivery to the CNS 227
Composition, Superoxide Radicals Scavenging and Antilipoperoxidant Activity of some Edible Fruits 226
Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors 226
Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors 226
Nanoparticelle polimeriche per il direzionamento di farmaci al Sistema Nervoso Centrale 224
Attivité antifongique in vitro de l’huille essentielle de chemotypes de lavandin 224
Identificazione, caratterizzazione e proprietà biologiche di derivati calconici da Glycyrrhiza Glabra L 221
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 220
Synthesis and aldose reductase inhibitory activity of a new series of benzo[h]cinnolinone derivatives 219
Totale 29.653
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Categoria #
all - tutte 152.799
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 152.799
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021474 0 0 0 0 0 0 0 0 0 0 298 176
2021/20223.031 93 396 425 199 79 155 167 206 290 200 487 334
2022/20233.139 417 341 225 281 420 479 73 246 410 54 114 79
2023/20241.868 69 119 105 191 431 178 177 246 57 51 79 165
2024/20256.613 287 86 133 447 1.315 925 450 424 663 416 696 771
2025/202612.001 696 503 1.195 1.752 2.514 981 1.355 641 1.183 970 211 0
Totale 41.827