TONDI, Donatella
 Distribuzione geografica
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Continente #
NA - Nord America 13.914
EU - Europa 8.712
AS - Asia 7.216
SA - Sud America 1.066
Continente sconosciuto - Info sul continente non disponibili 380
AF - Africa 157
OC - Oceania 24
Totale 31.469
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Nazione #
US - Stati Uniti d'America 13.625
IT - Italia 3.320
CN - Cina 2.021
GB - Regno Unito 1.996
SG - Singapore 1.987
VN - Vietnam 857
BR - Brasile 800
DE - Germania 748
HK - Hong Kong 735
SE - Svezia 673
FR - Francia 447
BD - Bangladesh 334
RU - Federazione Russa 327
UA - Ucraina 258
KR - Corea 256
TR - Turchia 246
IN - India 242
FI - Finlandia 236
CA - Canada 160
NL - Olanda 127
PL - Polonia 118
ID - Indonesia 109
BG - Bulgaria 105
AR - Argentina 101
JP - Giappone 87
MX - Messico 79
BE - Belgio 70
ES - Italia 57
IQ - Iraq 55
ZA - Sudafrica 54
PK - Pakistan 52
IE - Irlanda 48
CL - Cile 31
CO - Colombia 29
VE - Venezuela 29
EC - Ecuador 28
LT - Lituania 28
IR - Iran 27
MA - Marocco 27
TH - Thailandia 27
AT - Austria 23
AU - Australia 22
CH - Svizzera 22
MY - Malesia 22
AE - Emirati Arabi Uniti 19
DK - Danimarca 18
PE - Perù 18
JO - Giordania 17
RO - Romania 17
SA - Arabia Saudita 17
UZ - Uzbekistan 17
PH - Filippine 16
DZ - Algeria 14
KE - Kenya 14
EG - Egitto 13
EU - Europa 12
CZ - Repubblica Ceca 11
DO - Repubblica Dominicana 11
UY - Uruguay 11
BO - Bolivia 10
IL - Israele 10
TN - Tunisia 10
BY - Bielorussia 9
NP - Nepal 9
PT - Portogallo 9
TW - Taiwan 9
JM - Giamaica 8
KZ - Kazakistan 8
OM - Oman 8
PY - Paraguay 8
CR - Costa Rica 7
ET - Etiopia 7
RS - Serbia 7
AZ - Azerbaigian 6
PA - Panama 6
SK - Slovacchia (Repubblica Slovacca) 6
KG - Kirghizistan 5
HU - Ungheria 4
NI - Nicaragua 4
NO - Norvegia 4
QA - Qatar 4
SI - Slovenia 4
AL - Albania 3
CI - Costa d'Avorio 3
EE - Estonia 3
GR - Grecia 3
GT - Guatemala 3
HN - Honduras 3
AO - Angola 2
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
GE - Georgia 2
LB - Libano 2
MC - Monaco 2
MD - Moldavia 2
MN - Mongolia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SN - Senegal 2
Totale 31.074
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Città #
Houston 1.433
Santa Clara 1.322
Southend 1.275
Singapore 1.260
Ashburn 1.193
Fairfield 947
Woodbridge 747
Hong Kong 709
Chandler 701
San Jose 521
Hefei 511
Jacksonville 503
Dearborn 424
Ann Arbor 418
Wilmington 362
Cambridge 360
Seattle 359
Beijing 355
Nyköping 351
Modena 302
Frankfurt am Main 296
London 281
Ho Chi Minh City 275
Council Bluffs 229
Seoul 225
Rome 222
Los Angeles 217
New York 198
The Dalles 187
Milan 180
Hanoi 179
Helsinki 147
Princeton 115
Chicago 111
Sofia 103
Shanghai 101
Moscow 97
Eugene 96
Lauterbourg 96
Redwood City 91
San Diego 86
Izmir 80
São Paulo 76
Bremen 75
Jakarta 67
Buffalo 64
Kraków 61
Orem 61
Wildwood 60
Tokyo 57
Munich 54
Boardman 53
Dallas 50
Brussels 49
Florence 49
Naples 49
Guangzhou 48
Fremont 47
Padova 47
Nottingham 44
Chennai 43
Denver 43
Da Nang 42
Bologna 40
Columbus 40
Warsaw 40
Des Moines 39
Porto Alegre 39
Istanbul 37
Atlanta 36
Dublin 36
Nanjing 36
Napoli 36
Turin 36
Catania 35
Palermo 35
Salt Lake City 35
Montreal 34
Paris 32
Haiphong 31
Manchester 31
Ottawa 31
Brooklyn 30
Toronto 30
Bari 28
Dong Ket 28
Johannesburg 27
Mexico City 27
Philadelphia 27
Phoenix 26
San Francisco 26
Rio de Janeiro 24
Levallois-Perret 22
Redondo Beach 22
Ankara 21
Stockholm 21
Tampa 21
Turku 20
Austin 19
Biên Hòa 19
Totale 19.921
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Nome #
LexA e la risposta SOS nei batteri: design e ottimizzazione di inibitori contrastanti lo sviluppo della resistenza batterica. 2.424
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.224
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 490
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 453
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 430
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 389
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 388
Structure-based studies on species-specific inhibition of thymidylate synthase 379
Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 379
Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling. 368
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 362
Antibiotic Drug Discovery: New Targets and Molecular Entities. 361
Thymidylate synthase structure, function and implication in drug discovery 359
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 356
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 356
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 345
Crystal Structure of histidine-tagged human thymidylate synthase 344
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 335
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 331
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 330
ANTICANCER DRUGS 329
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 326
A multidisciplinary approach to the design of novel inhibitors for KPC-2 325
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 325
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-β-lactamase-1 316
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 311
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 311
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 311
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 310
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 294
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition 294
Crystallographic studies of novel inhibitors of [beta]-lactamases 293
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance. 293
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid 286
Ten years with NDM-1 metallo β-lactamase: from structural insights to inhibitor design 285
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture 283
Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) 283
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 280
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 279
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein 275
Discovery of a Novel Allosteric Inhibitor PK-188 Targeting New Delhi Metallo-β Lactamases. 273
Structure-based design of inhibitors specific for bacterial thymidylate synthase 268
Dal Ligand based design di inibitori della Timidilato Sintasi all'Analisi Comparativa dei Complessi Enzima-Inibitore 268
Discovery and preliminary characterization of a novel inhibitor of the SOS response in Pseudomonas aeruginosa 268
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 265
The SOS response in bacteria and the LexA transcriptional repressor. Boronic acids derivatives: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 261
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 260
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 258
Targeting the Class A Carbapenemase GES-5 via Virtual Screening 255
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases 249
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 249
The SOS response in bacteria and the LexA transcriptional repressor: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 249
Development of therapeutic agents blocking SOS activation. 248
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 248
Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-di(4'-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran 245
Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative 242
Structure-based inhibitor design vs. beta-lactamase 241
Thymidylate Synthase as a potential new target in drug resistance antimicrobial therapy. 240
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES 239
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid 239
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH 238
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase 234
3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use 232
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against RecA protein 228
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 228
Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance 226
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma 225
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture 224
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 224
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors? 223
Phenylboronic acid derivative inhibitors of beta-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 221
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma 220
Phenylboronic acid derivative inhibitors of ?-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 218
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase 211
Exploring acyclic boronic derivatives as potent beta-lactamases inhibitors with broad spectrum activity 200
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors 199
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 198
Rapid-Throughput Technologies Applied to the Discovery of New Hits against Thymidylate synthase Enzymes 193
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 190
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 190
"Structure-Based Discovery & In parallel Optimization of Novel Inhibitors of Thymidylate Synthase" 189
– IN SILICO SCREENING OF NOVEL INHIBITORS OF BETA-LACTAMASES 188
Structural and thermodynamic combined studies for inhibitors binding to Thymidylate Synthase 186
Sulfonamide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 186
Structural and Thermodynamic analysis of novel inhibitors of beta-lactmases. 185
Enhancement of the drug discovery process by integration of Structure-based drug design and combinatorial chemistry 184
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase 182
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases 179
Designing novel inhibitors for Metallo beta-lactamases. 179
Structure based design and combinatorial optimization of novel Thymidylate synthase inhibitors. Meeting Abstract : 217th ACS National Meeting, Chicago March 1999 179
A multidisciplinary approach in the successful identification of novel carbapenemases inhibitors 177
CTM-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 174
From ligand-based design to Hit validation of new thymidylate synthase inhibitors 173
Structure-Based Design and In Parallel Synthesis of Boronic Acid Inhibitors of AmpC 61538;-Lactamase 173
Acyclic boronic acids mimic β-Lactamases tetrahedral intermediates leading to broad spectrum inhibitors 173
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 172
Looking for broad-spectrum inhibitors targeting carbapenemases 172
Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors 168
Studi termodinamici e strutturali dell’interazione tra derivati densilici e Timidilato Sintasi Batteriche 167
VIrtual screening identifies cross-class inhibitors of clinically relevant serine- and metallo-beta lactamases 164
Totale 29.349
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Categoria #
all - tutte 103.078
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 103.078
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.876 80 215 116 115 78 130 95 111 233 123 340 240
2022/20232.571 258 257 175 232 279 362 94 254 277 63 170 150
2023/20242.097 85 105 121 158 607 174 172 201 49 116 126 183
2024/20255.083 208 102 154 349 994 668 458 266 518 156 526 684
2025/20269.245 506 446 666 1.143 1.348 672 1.016 553 918 841 629 507
2026/2027333 333 0 0 0 0 0 0 0 0 0 0 0
Totale 31.469