TONDI, Donatella
 Distribuzione geografica
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Continente #
NA - Nord America 12.082
EU - Europa 7.941
AS - Asia 5.197
SA - Sud America 835
AF - Africa 95
OC - Oceania 23
Continente sconosciuto - Info sul continente non disponibili 13
Totale 26.186
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Nazione #
US - Stati Uniti d'America 11.916
IT - Italia 2.958
GB - Regno Unito 1.943
CN - Cina 1.844
SG - Singapore 1.452
DE - Germania 723
SE - Svezia 671
BR - Brasile 669
HK - Hong Kong 644
VN - Vietnam 326
RU - Federazione Russa 310
FR - Francia 308
UA - Ucraina 249
TR - Turchia 227
IN - India 169
FI - Finlandia 160
KR - Corea 152
PL - Polonia 108
BG - Bulgaria 105
NL - Olanda 104
CA - Canada 100
ID - Indonesia 92
AR - Argentina 68
JP - Giappone 67
BE - Belgio 66
MX - Messico 45
ES - Italia 44
ZA - Sudafrica 43
IE - Irlanda 42
BD - Bangladesh 38
PK - Pakistan 29
IR - Iran 27
LT - Lituania 27
TH - Thailandia 25
IQ - Iraq 23
AT - Austria 21
AU - Australia 21
CO - Colombia 21
CH - Svizzera 19
EC - Ecuador 19
CL - Cile 18
MA - Marocco 17
DK - Danimarca 16
MY - Malesia 13
PE - Perù 13
EU - Europa 12
RO - Romania 12
VE - Venezuela 11
CZ - Repubblica Ceca 9
EG - Egitto 9
IL - Israele 9
SA - Arabia Saudita 9
AE - Emirati Arabi Uniti 8
PT - Portogallo 8
TN - Tunisia 8
DO - Repubblica Dominicana 7
JO - Giordania 7
KE - Kenya 7
PY - Paraguay 7
RS - Serbia 7
UZ - Uzbekistan 6
PH - Filippine 5
SK - Slovacchia (Repubblica Slovacca) 5
TW - Taiwan 5
UY - Uruguay 5
BY - Bielorussia 4
HU - Ungheria 4
KZ - Kazakistan 4
PA - Panama 4
BO - Bolivia 3
CR - Costa Rica 3
GR - Grecia 3
JM - Giamaica 3
KG - Kirghizistan 3
OM - Oman 3
CI - Costa d'Avorio 2
DZ - Algeria 2
EE - Estonia 2
MC - Monaco 2
NG - Nigeria 2
NO - Norvegia 2
NP - Nepal 2
NZ - Nuova Zelanda 2
SI - Slovenia 2
A1 - Anonimo 1
AL - Albania 1
AN - Antille olandesi 1
AO - Angola 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BZ - Belize 1
GA - Gabon 1
GE - Georgia 1
GY - Guiana 1
HN - Honduras 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
LI - Liechtenstein 1
LV - Lettonia 1
MD - Moldavia 1
Totale 26.176
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Città #
Houston 1.431
Southend 1.275
Santa Clara 1.259
Fairfield 947
Singapore 872
Ashburn 869
Woodbridge 747
Chandler 701
Hong Kong 636
Hefei 510
Jacksonville 502
Dearborn 424
Ann Arbor 418
Wilmington 361
Seattle 358
Nyköping 351
Cambridge 350
Beijing 307
Modena 296
Frankfurt am Main 285
London 274
Rome 208
Los Angeles 171
New York 158
Seoul 139
Ho Chi Minh City 121
Milan 119
Council Bluffs 118
Princeton 113
Sofia 103
The Dalles 98
Chicago 96
Shanghai 96
Eugene 95
Moscow 95
Redwood City 91
San Diego 85
Izmir 80
Bremen 75
Helsinki 71
São Paulo 68
Jakarta 65
Hanoi 64
Kraków 61
Wildwood 60
Munich 54
Buffalo 51
Brussels 49
Boardman 47
Florence 47
Padova 47
Fremont 46
Guangzhou 45
Nottingham 44
San Jose 44
Tokyo 44
Naples 41
Denver 40
Columbus 38
Dallas 38
Des Moines 37
Napoli 36
Nanjing 35
Catania 34
Warsaw 34
Bologna 33
Dublin 32
Istanbul 32
Salt Lake City 32
Turin 32
Ottawa 30
Brooklyn 28
Dong Ket 28
Palermo 28
Bari 27
Montreal 26
Paris 26
Johannesburg 23
Levallois-Perret 22
Manchester 22
Redondo Beach 22
Rio de Janeiro 22
Toronto 22
Atlanta 21
Chennai 21
Philadelphia 21
San Francisco 21
Tampa 20
Turku 20
Phoenix 19
Stockholm 19
Kent 18
St Louis 18
Orem 17
Brisbane 16
San Mateo 16
Belo Horizonte 15
Brasília 15
Changsha 15
Elk Grove Village 15
Totale 17.268
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Nome #
LexA e la risposta SOS nei batteri: design e ottimizzazione di inibitori contrastanti lo sviluppo della resistenza batterica. 2.265
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.158
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 408
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 406
Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 346
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 342
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 340
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 324
Structure-based studies on species-specific inhibition of thymidylate synthase 321
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 320
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 306
Crystal Structure of histidine-tagged human thymidylate synthase 300
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 294
Antibiotic Drug Discovery: New Targets and Molecular Entities. 292
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-β-lactamase-1 286
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 284
ANTICANCER DRUGS 283
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 282
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 281
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 280
Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling. 278
Thymidylate synthase structure, function and implication in drug discovery 277
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 276
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 272
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 265
A multidisciplinary approach to the design of novel inhibitors for KPC-2 264
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 259
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture 253
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 252
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 250
Ten years with NDM-1 metallo β-lactamase: from structural insights to inhibitor design 249
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 246
Discovery of a Novel Allosteric Inhibitor PK-188 Targeting New Delhi Metallo-β Lactamases. 246
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 243
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid 243
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance. 243
Structure-based design of inhibitors specific for bacterial thymidylate synthase 240
Dal Ligand based design di inibitori della Timidilato Sintasi all'Analisi Comparativa dei Complessi Enzima-Inibitore 234
Targeting the Class A Carbapenemase GES-5 via Virtual Screening 233
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 231
The SOS response in bacteria and the LexA transcriptional repressor. Boronic acids derivatives: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 230
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein 229
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 228
Crystallographic studies of novel inhibitors of [beta]-lactamases 226
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 226
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition 225
Discovery and preliminary characterization of a novel inhibitor of the SOS response in Pseudomonas aeruginosa 222
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 221
Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative 217
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 217
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases 216
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 216
Development of therapeutic agents blocking SOS activation. 215
Thymidylate Synthase as a potential new target in drug resistance antimicrobial therapy. 212
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES 211
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 208
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase 207
Structure-based inhibitor design vs. beta-lactamase 203
Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-di(4'-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran 203
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid 202
Phenylboronic acid derivative inhibitors of ?-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 198
The SOS response in bacteria and the LexA transcriptional repressor: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 198
3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use 193
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 193
Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance 192
Phenylboronic acid derivative inhibitors of beta-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 191
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma 191
Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) 186
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH 185
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma 185
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture 180
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors? 176
Rapid-Throughput Technologies Applied to the Discovery of New Hits against Thymidylate synthase Enzymes 173
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against RecA protein 172
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase 172
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors 172
Structural and thermodynamic combined studies for inhibitors binding to Thymidylate Synthase 166
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 166
Structural and Thermodynamic analysis of novel inhibitors of beta-lactmases. 164
Sulfonamide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 162
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 159
Studi termodinamici e strutturali dell’interazione tra derivati densilici e Timidilato Sintasi Batteriche 157
Designing novel inhibitors for Metallo beta-lactamases. 156
Structure-Based Design and In Parallel Synthesis of Boronic Acid Inhibitors of AmpC 61538;-Lactamase 155
Exploring acyclic boronic derivatives as potent beta-lactamases inhibitors with broad spectrum activity 154
Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors 152
Enhancement of the drug discovery process by integration of Structure-based drug design and combinatorial chemistry 151
CTM-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 148
From ligand-based design to Hit validation of new thymidylate synthase inhibitors 148
A multidisciplinary approach in the successful identification of novel carbapenemases inhibitors 148
Looking for broad-spectrum inhibitors targeting carbapenemases 147
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase 146
Acyclic boronic acids mimic β-Lactamases tetrahedral intermediates leading to broad spectrum inhibitors 146
Structure based design and combinatorial optimization of novel Thymidylate synthase inhibitors. Meeting Abstract : 217th ACS National Meeting, Chicago March 1999 141
"Structure-Based Discovery & In parallel Optimization of Novel Inhibitors of Thymidylate Synthase" 140
VIrtual screening identifies cross-class inhibitors of clinically relevant serine- and metallo-beta lactamases 140
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 137
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases 136
– IN SILICO SCREENING OF NOVEL INHIBITORS OF BETA-LACTAMASES 130
Structure-based discovery and combinatorial optimization of novel competitive inhibitors of thymidylate synthase 128
Totale 25.040
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Categoria #
all - tutte 88.722
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 88.722
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.527 0 0 0 0 0 184 235 245 124 357 229 153
2021/20221.876 80 215 116 115 78 130 95 111 233 123 340 240
2022/20232.571 258 257 175 232 279 362 94 254 277 63 170 150
2023/20242.097 85 105 121 158 607 174 172 201 49 116 126 183
2024/20255.083 208 102 154 349 994 668 458 266 518 156 526 684
2025/20264.659 506 446 666 1.143 1.348 550 0 0 0 0 0 0
Totale 26.550