TONDI, Donatella
 Distribuzione geografica
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Continente #
NA - Nord America 13.209
EU - Europa 8.478
AS - Asia 6.881
SA - Sud America 1.056
AF - Africa 156
OC - Oceania 24
Continente sconosciuto - Info sul continente non disponibili 13
Totale 29.817
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Nazione #
US - Stati Uniti d'America 12.964
IT - Italia 3.105
GB - Regno Unito 1.992
CN - Cina 1.985
SG - Singapore 1.971
VN - Vietnam 854
BR - Brasile 794
DE - Germania 747
HK - Hong Kong 731
SE - Svezia 673
FR - Francia 444
RU - Federazione Russa 327
UA - Ucraina 258
TR - Turchia 245
IN - India 241
KR - Corea 240
FI - Finlandia 236
CA - Canada 127
NL - Olanda 125
PL - Polonia 118
ID - Indonesia 109
BG - Bulgaria 105
AR - Argentina 100
BD - Bangladesh 85
JP - Giappone 84
MX - Messico 77
BE - Belgio 70
IQ - Iraq 55
ES - Italia 54
ZA - Sudafrica 54
PK - Pakistan 50
IE - Irlanda 47
CL - Cile 31
VE - Venezuela 29
CO - Colombia 28
EC - Ecuador 27
IR - Iran 27
LT - Lituania 27
TH - Thailandia 27
MA - Marocco 26
AT - Austria 23
AU - Australia 22
CH - Svizzera 22
MY - Malesia 20
AE - Emirati Arabi Uniti 19
DK - Danimarca 18
PE - Perù 17
SA - Arabia Saudita 17
UZ - Uzbekistan 17
JO - Giordania 16
PH - Filippine 16
RO - Romania 16
DZ - Algeria 14
KE - Kenya 14
EG - Egitto 13
EU - Europa 12
DO - Repubblica Dominicana 11
UY - Uruguay 11
BO - Bolivia 10
CZ - Repubblica Ceca 10
IL - Israele 10
TN - Tunisia 10
BY - Bielorussia 9
NP - Nepal 9
PT - Portogallo 9
KZ - Kazakistan 8
OM - Oman 8
PY - Paraguay 8
TW - Taiwan 8
ET - Etiopia 7
RS - Serbia 7
AZ - Azerbaigian 6
CR - Costa Rica 6
JM - Giamaica 6
PA - Panama 6
SK - Slovacchia (Repubblica Slovacca) 6
KG - Kirghizistan 5
HU - Ungheria 4
NI - Nicaragua 4
QA - Qatar 4
SI - Slovenia 4
AL - Albania 3
CI - Costa d'Avorio 3
EE - Estonia 3
GR - Grecia 3
NO - Norvegia 3
AO - Angola 2
BH - Bahrain 2
GE - Georgia 2
HN - Honduras 2
LB - Libano 2
MC - Monaco 2
MD - Moldavia 2
MN - Mongolia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SN - Senegal 2
SY - Repubblica araba siriana 2
TZ - Tanzania 2
Totale 29.794
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Città #
Houston 1.432
Santa Clara 1.291
Southend 1.275
Singapore 1.256
Ashburn 1.086
Fairfield 947
Woodbridge 747
Hong Kong 706
Chandler 701
Hefei 511
Jacksonville 502
San Jose 425
Dearborn 424
Ann Arbor 418
Wilmington 362
Seattle 358
Nyköping 351
Cambridge 350
Beijing 349
Modena 296
Frankfurt am Main 295
London 281
Ho Chi Minh City 274
Seoul 225
Rome 213
The Dalles 187
Los Angeles 183
Hanoi 179
New York 171
Council Bluffs 168
Milan 150
Helsinki 147
Princeton 113
Chicago 106
Sofia 103
Shanghai 98
Moscow 97
Lauterbourg 96
Eugene 95
Redwood City 91
San Diego 85
Izmir 80
Bremen 75
São Paulo 75
Jakarta 67
Kraków 61
Orem 61
Wildwood 60
Tokyo 57
Munich 54
Buffalo 52
Brussels 49
Boardman 48
Florence 47
Padova 47
Fremont 46
Guangzhou 46
Nottingham 44
Chennai 43
Dallas 43
Denver 43
Naples 43
Da Nang 42
Warsaw 40
Columbus 39
Des Moines 39
Porto Alegre 38
Dublin 36
Istanbul 36
Nanjing 36
Napoli 36
Salt Lake City 35
Atlanta 34
Catania 34
Bologna 33
Turin 33
Paris 32
Manchester 31
Ottawa 31
Haiphong 30
Montreal 29
Palermo 29
Brooklyn 28
Dong Ket 28
Bari 27
Johannesburg 27
Mexico City 26
San Francisco 24
Toronto 24
Rio de Janeiro 23
Levallois-Perret 22
Redondo Beach 22
Ankara 21
Philadelphia 21
Phoenix 21
Stockholm 21
Tampa 20
Turku 20
Biên Hòa 19
Brasília 19
Totale 19.391
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Nome #
LexA e la risposta SOS nei batteri: design e ottimizzazione di inibitori contrastanti lo sviluppo della resistenza batterica. 2.371
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase 1.197
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase 482
An Improved Synthesis of CENTA, a Chromogenic Substrate for β-Lactamases 448
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 382
Constrained dansyl derivatives reveal bacterial specificity of highly conserved Thymidylate Synthases A 374
Structure-based studies on species-specific inhibition of thymidylate synthase 372
Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 372
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine 356
Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-beta-lactamases 352
Decoding the structural basis for carbapenem hydrolysis by class A β- lactamases: fishing for a pharmacophore 348
Multiligand approach to the identification of resistant strains overexpressing beta-lactamase 345
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor 339
Crystal Structure of histidine-tagged human thymidylate synthase 335
Antibiotic Drug Discovery: New Targets and Molecular Entities. 327
Mono- and Disubstituted-3,8-diazabicyclo[3.2.1]octane Derivatives as Analgesics Structurally Related to Epibatidine: Synthesis, Activity, and Modeling. 325
Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations 324
ANTICANCER DRUGS 322
“A step further in the discovery of phthalein derivatives as Thymidylate Synthase inhibitors” 317
Structure-based virtual screening for the discovery of novel inhibitors of New Delhi Metallo-β-lactamase-1 314
1H-NMR conformational studies of some phtalein derivatives acting as thymidylate synthase inhibitors 309
Thymidylate synthase structure, function and implication in drug discovery 309
The Inhibition of Extended Spectrum beta-Lactamases: Hits and Leads 307
X-ray-crystallography deciphers the activity of broad spectrum boronic acid β-Lactamases inhibitors 306
IN SILICO/IN VITRO APPROACHES FOR THE IDENTIFICATION OF NEW CARBAPENEMASE INHIBITORS 305
A multidisciplinary approach to the design of novel inhibitors for KPC-2 304
4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases 299
First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase 294
Optimizing Cell Permeation of an Antibiotic Resistance Inhibitor for Improved Efficacy 281
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture 280
AmpC beta-lactamase in complex with 3-(3-nitro-phenylsulfamoyl)-thiophene-2-carboxylic acid 278
3-Aminophenylboronic acid derivative inhibitors of beta-lactamases, their preparation, and their therapeutic use. 276
Erratum: Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 34 (E542-E549) DOI: 10.1073/pnas.1104829108) 274
Design, synthesis and biological evaluation of non-covalent AmpC Beta-Lactamases inhibitors 272
Ten years with NDM-1 metallo β-lactamase: from structural insights to inhibitor design 271
Discovery of a Novel Allosteric Inhibitor PK-188 Targeting New Delhi Metallo-β Lactamases. 269
Structure-based design of inhibitors specific for bacterial thymidylate synthase 266
Dal Ligand based design di inibitori della Timidilato Sintasi all'Analisi Comparativa dei Complessi Enzima-Inibitore 266
Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition 266
Crystallographic studies of novel inhibitors of [beta]-lactamases 263
Amide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 262
Discovery and preliminary characterization of a novel inhibitor of the SOS response in Pseudomonas aeruginosa 262
Phenyl boronic acids development led to validated leads active in clinical strains overexpressing KPC-2: a step against bacterial resistance. 261
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein 260
AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid 257
The SOS response in bacteria and the LexA transcriptional repressor. Boronic acids derivatives: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 255
New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics
 253
Targeting the Class A Carbapenemase GES-5 via Virtual Screening 251
In silico identification and experimental validation of hits active against KPC-2 β-lactamase 249
Structure-Based Optimization of a Non-β-lactam Lead Results in Inhibitors That Do Not Up-Regulate β-Lactamase Expression in Cell Culture 248
Development of therapeutic agents blocking SOS activation. 247
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases 245
Ortho-halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity 244
Structure-based inhibitor design vs. beta-lactamase 241
The SOS response in bacteria and the LexA transcriptional repressor: withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 237
AmpC beta-lactamase in complex with 5-diformylaminomethyl-benzo[b]thiophen-2-boronic acid 237
Thymidylate Synthase as a potential new target in drug resistance antimicrobial therapy. 236
NAPHTHOFURANONE DERIVATIVES AS SPECIFIC INHIBITORS OF THYMIDYLATE SYNTHASES 235
Separation, structural determination and biological evaluation of the thymidylate synthase inhibitor 3,3-di(4'-hydroxyphenyl)-6(7)-chloro-1-oxo-1H,3H-naphtho[1,8-cd]pyran 233
Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative 232
Structure-based design and in-parallel synthesis of inhibitors of AmpC β-lactamase 228
DESIGNING NOVEL INHIBITORS FOR CARBAPENEMASES: A MULTIDISCIPLINARY APPROACH 227
3-Aminophenylboronic acid derivative inhibitors of β-lactamases, their preparation, and their therapeutic use 226
Characterisation and Optimisation of Anti-LexA Nanobodies Targeting the SOS-response Pathway to Fight Antibiotic Resistance 223
Interfering with Human Thymidylate Synthase Dimerization against ovarian human carcinoma 222
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 221
Naphthalimido Derivatives as Antifolate Thymidylate Synthase Inhibitors 220
Phenylboronic acid derivative inhibitors of beta-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 219
Interfering with Human Thymidylate Synthase Dimerization anti peptide design in the search of anticancer agents against ovarian human carcinoma 217
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors? 217
Phenylboronic acid derivative inhibitors of ?-lactamases, their preparation, pharmaceutical compositions, and therapeutic use. 215
SOS response in bacteria: inhibitory activity of lichen secondary metabolites against RecA protein 211
Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture 206
Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase 198
Rapid-Throughput Technologies Applied to the Discovery of New Hits against Thymidylate synthase Enzymes 192
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors 188
Structural and thermodynamic combined studies for inhibitors binding to Thymidylate Synthase 184
Sulfonamide Boronic Acid Inhibitors of AmpC b-lactamase to Reverse Bacterial Resistance to b-lactam Antibiotics. 184
Structural and Thermodynamic analysis of novel inhibitors of beta-lactmases. 183
Enhancement of the drug discovery process by integration of Structure-based drug design and combinatorial chemistry 182
Inhibition of the transcriptional repressor LexA: Withstanding drug resistance by inhibiting the bacterial mechanisms of adaptation to antimicrobials 182
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 180
"Structure-Based Discovery & In parallel Optimization of Novel Inhibitors of Thymidylate Synthase" 179
Exploring acyclic boronic derivatives as potent beta-lactamases inhibitors with broad spectrum activity 175
A multidisciplinary approach in the successful identification of novel carbapenemases inhibitors 175
Intersite Communication in Dimeric Enzymes Highlighted by Structural and Thermodynamic Analysis of Didansyltyrosine Binding to Thymidylate Synthases 173
Designing novel inhibitors for Metallo beta-lactamases. 173
Structure-based design and in parallel synthesis of boronic acid inhibitors of AmpC beta-lactamase 173
CTM-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid 172
Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases 172
Structure-Based Design and In Parallel Synthesis of Boronic Acid Inhibitors of AmpC 61538;-Lactamase 171
Acyclic boronic acids mimic β-Lactamases tetrahedral intermediates leading to broad spectrum inhibitors 170
From ligand-based design to Hit validation of new thymidylate synthase inhibitors 169
Structure based design and combinatorial optimization of novel Thymidylate synthase inhibitors. Meeting Abstract : 217th ACS National Meeting, Chicago March 1999 168
Studi termodinamici e strutturali dell’interazione tra derivati densilici e Timidilato Sintasi Batteriche 167
Looking for broad-spectrum inhibitors targeting carbapenemases 167
– IN SILICO SCREENING OF NOVEL INHIBITORS OF BETA-LACTAMASES 165
Structure-based design and solid phase synthesis of novel AmpC b-lactamase inhibitors 165
VIrtual screening identifies cross-class inhibitors of clinically relevant serine- and metallo-beta lactamases 164
Phenylboronic Acids Probing Molecular Recognition against Class A and Class C beta-Lactamases 162
Totale 28.227
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Categoria #
all - tutte 96.019
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 96.019
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021382 0 0 0 0 0 0 0 0 0 0 229 153
2021/20221.876 80 215 116 115 78 130 95 111 233 123 340 240
2022/20232.571 258 257 175 232 279 362 94 254 277 63 170 150
2023/20242.097 85 105 121 158 607 174 172 201 49 116 126 183
2024/20255.083 208 102 154 349 994 668 458 266 518 156 526 684
2025/20268.290 506 446 666 1.143 1.348 672 1.016 553 918 841 181 0
Totale 30.181