D'ARCA, Domenico
 Distribuzione geografica
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Continente #
NA - Nord America 7.492
EU - Europa 4.052
AS - Asia 3.380
SA - Sud America 472
AF - Africa 42
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 1
Totale 15.447
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Nazione #
US - Stati Uniti d'America 7.399
CN - Cina 1.201
IT - Italia 1.167
SG - Singapore 1.076
GB - Regno Unito 936
SE - Svezia 476
DE - Germania 411
HK - Hong Kong 394
BR - Brasile 385
RU - Federazione Russa 209
FR - Francia 192
VN - Vietnam 164
FI - Finlandia 113
KR - Corea 112
UA - Ucraina 103
PL - Polonia 97
ID - Indonesia 89
IN - India 67
TR - Turchia 63
CA - Canada 61
JP - Giappone 53
ES - Italia 51
IE - Irlanda 49
BG - Bulgaria 46
NL - Olanda 42
LT - Lituania 41
BE - Belgio 39
AR - Argentina 37
BD - Bangladesh 29
MX - Messico 25
CH - Svizzera 20
PK - Pakistan 18
AT - Austria 17
IQ - Iraq 16
ZA - Sudafrica 15
CL - Cile 14
CO - Colombia 12
TW - Taiwan 12
SA - Arabia Saudita 11
EC - Ecuador 9
MY - Malesia 9
CZ - Repubblica Ceca 8
MA - Marocco 8
RO - Romania 8
UZ - Uzbekistan 8
DK - Danimarca 6
KE - Kenya 6
AE - Emirati Arabi Uniti 5
AU - Australia 5
EG - Egitto 5
IL - Israele 5
KZ - Kazakistan 5
LB - Libano 5
UY - Uruguay 5
AZ - Azerbaigian 4
BH - Bahrain 4
GR - Grecia 4
IR - Iran 4
PH - Filippine 4
PY - Paraguay 4
GE - Georgia 3
NO - Norvegia 3
NP - Nepal 3
NZ - Nuova Zelanda 3
PE - Perù 3
PT - Portogallo 3
RS - Serbia 3
VE - Venezuela 3
AL - Albania 2
AM - Armenia 2
BY - Bielorussia 2
DZ - Algeria 2
HU - Ungheria 2
JM - Giamaica 2
JO - Giordania 2
LK - Sri Lanka 2
MO - Macao, regione amministrativa speciale della Cina 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
TN - Tunisia 2
BN - Brunei Darussalam 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
ET - Etiopia 1
EU - Europa 1
GT - Guatemala 1
KG - Kirghizistan 1
MD - Moldavia 1
MK - Macedonia 1
NG - Nigeria 1
OM - Oman 1
PA - Panama 1
PS - Palestinian Territory 1
RE - Reunion 1
SV - El Salvador 1
ZM - Zambia 1
Totale 15.447
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Città #
Santa Clara 805
Fairfield 783
Ashburn 752
Singapore 643
Southend 574
Hefei 457
Woodbridge 437
Chandler 435
Hong Kong 384
Houston 350
Ann Arbor 336
Seattle 303
Cambridge 277
Modena 271
Wilmington 258
Nyköping 254
Jacksonville 191
Dearborn 187
London 176
Beijing 174
New York 170
Frankfurt am Main 145
Los Angeles 134
Seoul 101
Bologna 82
Chicago 76
San Diego 75
Jakarta 72
Kraków 69
Munich 68
The Dalles 61
Helsinki 58
Ho Chi Minh City 56
Moscow 55
Princeton 51
Shanghai 51
Fremont 50
Dublin 47
Sofia 46
Eugene 44
São Paulo 41
Council Bluffs 39
Milan 37
Dallas 36
Parma 35
Boardman 34
Izmir 33
Salt Lake City 33
Hanoi 32
Brussels 29
Buffalo 29
Phoenix 27
Tokyo 27
Warsaw 26
Denver 24
Redwood City 22
Bremen 21
Columbus 21
Guangzhou 21
Reggio Emilia 21
Kent 20
Padova 20
Rome 19
Toronto 19
Orem 18
Brooklyn 16
Formigine 16
Verona 16
Boston 15
Piacenza 15
Poplar 15
Tampa 15
Turku 15
Dong Ket 14
Falls Church 14
Montreal 14
Chennai 13
Des Moines 13
Elk Grove Village 13
Portsmouth 13
Rio de Janeiro 13
Washington 13
Zurich 13
Amsterdam 12
Atlanta 12
Barcelona 12
Lappeenranta 12
Miami 12
Nanjing 12
Norwalk 12
Paris 12
San Jose 12
Stockholm 12
Vienna 12
Nuremberg 11
Osnabrück 11
Ferrara 10
Jinan 10
Manchester 10
Ottawa 10
Totale 10.692
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Nome #
Spermidine/spermine N1-acetyltransferase transient over-expression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin 417
Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth 360
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth 356
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 346
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 342
Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery 340
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 334
Clusterin decreases oxidative stress in lung fibroblasts exposed to cigarette smoke 333
Repurposing of drugs targeting yap-tead functions 333
Inside the biochemical pathways of thymidylate synthase perturbed by anticancer drugs: Novel strategies to overcome cancer chemoresistance 327
Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides 320
Proteomic and bioinformatic studies for the characterization of response to pemetrexed in platinum drug resistant ovarian cancer 315
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells 312
pH-Promoted Release of a Novel Anti-Tumour Peptide by “Stealth” Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells 302
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 292
Involvement of epigenetic modification of TERT promoter in response to all-trans retinoic acid in ovarian cancer cell lines 290
Targeting Oxidatively Induced DNA Damage Response in Cancer: Opportunities for Novel Cancer Therapies 287
ANTICANCER DRUGS 283
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases 280
PTEROATE-PEPTIDE BIOCONJUGATE TARGETING THE FOLATE RECEPTOR IN HUMAN OVARIAN CANCER CELL LINES: TRANSPORT AND MECHANISM OF ACTION. 277
Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin 270
Mitostatin, a novel mitochondrial protein, that acts as a tumor suppressor in prostate cancer cells 266
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 264
Clusterin (SGP-2, ApoJ) expression is downregulated in low- and high-grade human prostate cancer 255
Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor 253
Depletion of Trichoplein (TpMs) Causes Chromosome Mis-Segregation, DNA Damage and Chromosome Instability in Cancer Cells 252
The 1,10-phenanthroline ligand enhances the antiproliferative activity of dna-intercalating thiourea-pd(Ii) and-pt(ii) complexes against cisplatin-sensitive and-resistant human ovarian cancer cell lines 250
Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum 246
MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer 245
The key role of Mitostatin in the maintenance of genome stability 245
Anticancer activity of green tea polyphenols in prostate gland 245
pH sensitive PEGylated Liposomes delivering active hydrophilic peptide with anticancer activity: in vitro study on cDDP-resistant ovarian cell line 241
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth 241
The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. 228
The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression 220
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 214
Nuclear Translocation of a Clusterin Isoform Is Associated with Induction of Anoikis in SV40-Immortalized Human Prostate Epithelial Cells 213
MITOSTATIN, A NOVEL MITOCHONDRIAL PROTEIN, THAT ACTS AS A TUMOR SUPPRESSOR IN PROSTATE CANCER CELLS 213
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer 200
Mitostatin Is Down-Regulated in Human Prostate Cancer and Suppresses the Invasive Phenotype of Prostate Cancer Cells 200
Clusterin is down-regulated during the progression of prostate cancer in the tramp mouse model but up-regulated during chemioprevention by green tea catechins administration 199
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma 191
Clusterin gene expression is down-regulated in transformed epithelial cells but up-regulated in fibroblasts from prostate cancer 191
LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients 190
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties 189
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma 187
Prevention of bladder cancer in the FHIT knock-out mouse model with rofecoxib, a COX-2 inhibitor 187
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA 181
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy 177
Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations 168
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library 167
Targeting the dimer-monomer equilibrium of thymidylate synthase, to accelerate protein degradation and cancer cell growth inhibition 160
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles 154
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase 153
Telomere Dysfunction Is Associated with Altered {DNA} Organization in Trichoplein/Tchp/Mitostatin ({TpMs}) Depleted Cells 153
Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation 148
Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer 147
Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay 146
Bioaccessibility of Flavones, Flavanones, and Flavonols from Vegetable Foods and Beverages 143
Precision medicine through proteomics studies in drug resistant colorectal cancer 141
Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems 141
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme 139
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA 137
Successful prediction of prostate cancer recurrence by gene profiling in combination with clinical data: a 5-year follow-up study. 126
Optical tweezers to investigate at the single-molecule level the interaction of thymidylate synthase with its consensus mRNA 123
MS Proteomics And Biochemical Characterization Of Thymidylate Synthase Dimer Destabilizer E7 To Halt Colorectal Carcinoma 105
Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment 98
Targeting the Interplay of Independent Cellular Pathways and Immunity: A Challenge in Cancer Immunotherapy 97
Development of a fluorescent anisotropy displacement assay for the optimization of YAP:TEAD molecular disrupters with anticancer activity 54
IDENTIFICATION OF PYRAZOLO-PIPERIDINONE DERIVATIVES TARGETING YAP-TEAD INTERFACE 3 AS ANTICANCER AGENTS THROUGH INTEGRATED VIRTUAL SCREENING AND MASS SPECTROMETRY PROTEOMICS 39
Totale 15.638
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Categoria #
all - tutte 59.150
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.150
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.165 0 0 0 0 0 128 125 208 88 341 160 115
2021/20221.185 51 111 71 60 52 106 66 65 129 92 249 133
2022/20231.383 162 172 104 133 150 154 72 135 147 27 67 60
2023/20241.333 56 92 103 75 372 134 65 75 28 40 152 141
2024/20253.532 116 51 109 233 661 498 258 234 356 144 397 475
2025/20263.251 472 285 457 710 956 371 0 0 0 0 0 0
Totale 15.638