FRANCHINI, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 13.805
EU - Europa 8.398
AS - Asia 6.414
SA - Sud America 935
Continente sconosciuto - Info sul continente non disponibili 221
AF - Africa 152
OC - Oceania 37
Totale 29.962
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Nazione #
US - Stati Uniti d'America 13.498
GB - Regno Unito 2.046
SG - Singapore 1.784
IT - Italia 1.671
CN - Cina 1.661
DE - Germania 1.292
SE - Svezia 1.012
VN - Vietnam 827
HK - Hong Kong 755
BR - Brasile 726
FI - Finlandia 564
RU - Federazione Russa 415
FR - Francia 316
UA - Ucraina 256
BD - Bangladesh 249
KR - Corea 215
TR - Turchia 203
IN - India 202
CA - Canada 169
BE - Belgio 145
BG - Bulgaria 120
NL - Olanda 116
PL - Polonia 102
IE - Irlanda 87
ID - Indonesia 81
MX - Messico 77
JP - Giappone 67
AR - Argentina 54
IQ - Iraq 51
RO - Romania 50
LT - Lituania 42
EC - Ecuador 41
ES - Italia 39
IR - Iran 32
AE - Emirati Arabi Uniti 31
CO - Colombia 31
ZA - Sudafrica 30
AT - Austria 26
NZ - Nuova Zelanda 26
PK - Pakistan 26
SA - Arabia Saudita 25
CL - Cile 24
EG - Egitto 24
IL - Israele 24
VE - Venezuela 23
TW - Taiwan 22
UZ - Uzbekistan 20
KE - Kenya 19
PH - Filippine 19
TH - Thailandia 18
CH - Svizzera 17
JO - Giordania 17
MA - Marocco 17
MY - Malesia 14
NO - Norvegia 13
PY - Paraguay 13
CZ - Repubblica Ceca 12
AU - Australia 11
KZ - Kazakistan 11
PE - Perù 11
TN - Tunisia 11
CR - Costa Rica 10
DZ - Algeria 10
JM - Giamaica 10
PT - Portogallo 10
AZ - Azerbaigian 9
CI - Costa d'Avorio 8
NG - Nigeria 7
NI - Nicaragua 7
SN - Senegal 7
BO - Bolivia 6
EU - Europa 6
PR - Porto Rico 6
AL - Albania 5
BH - Bahrain 5
DK - Danimarca 5
DO - Repubblica Dominicana 5
GT - Guatemala 5
LB - Libano 5
LU - Lussemburgo 5
NP - Nepal 5
OM - Oman 5
PS - Palestinian Territory 5
BY - Bielorussia 4
HU - Ungheria 4
RS - Serbia 4
UY - Uruguay 4
BZ - Belize 3
CY - Cipro 3
ET - Etiopia 3
GR - Grecia 3
HN - Honduras 3
LK - Sri Lanka 3
QA - Qatar 3
SC - Seychelles 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
TZ - Tanzania 3
UG - Uganda 3
AM - Armenia 2
Totale 29.700
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Città #
Southend 1.253
Ashburn 1.192
Santa Clara 1.180
Singapore 1.092
Fairfield 813
Chandler 758
Hong Kong 710
Woodbridge 606
Ann Arbor 578
Munich 536
San Jose 529
Hefei 505
Houston 498
Nyköping 463
Jacksonville 462
Helsinki 430
Chicago 412
Dearborn 379
New York 369
Seattle 366
London 365
Beijing 350
Wilmington 342
Los Angeles 314
Cambridge 279
Dallas 258
Ho Chi Minh City 253
Modena 242
Council Bluffs 236
Berlin 211
Hanoi 193
Seoul 179
Brussels 141
Salt Lake City 129
Milan 119
Sofia 116
The Dalles 114
Frankfurt am Main 105
Princeton 99
Eugene 97
San Diego 90
Dublin 84
Izmir 81
Lauterbourg 80
Elk Grove Village 78
Buffalo 76
Moscow 74
Orem 69
Amsterdam 66
Tampa 66
Fremont 65
São Paulo 64
Des Moines 63
Tokyo 57
Toronto 57
Shanghai 56
Bologna 55
Redwood City 50
Warsaw 47
Boardman 46
Jakarta 46
Da Nang 44
Bremen 42
Yalova 41
Kraków 39
Mumbai 38
Mexico City 37
Rome 37
Phoenix 36
Shenzhen 35
Turku 33
Grafing 32
Columbus 31
Sterling 31
Boston 30
Haiphong 30
Montreal 30
Philadelphia 27
Verona 27
Atlanta 26
Auckland 26
Norwalk 26
Chennai 25
Denver 25
Lancaster 25
Brooklyn 24
Milwaukee 24
Hillsboro 23
Augusta 22
Guangzhou 22
Jyväskylä 22
Sochi 22
West Jordan 22
Parma 21
Saint Petersburg 21
Falls Church 20
Kent 20
Reggio Emilia 20
Baghdad 19
Paris 19
Totale 19.737
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Nome #
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands 981
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 812
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors 751
(2,2-difenil-[1,3]-diossolan-4ilmetil)-(3-fenil-propil)-ammina: nuovo agonista parziale del recettore serotoninergico 5-HT1A 644
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 581
1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists 528
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors 498
1,3-dioxolane-based ligands in the search for alpha1-adrenergic antagonists. 449
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study 447
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist 446
Synthesis and pharmacological evaluation of 1-benzylpiperazine and 4-benzylpiperidine as potent sigma ligands. 441
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression 428
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain. 414
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 403
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury 401
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues 394
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 379
Cloning and purification of the Rainbow Trout fifth component of complement (C5). 371
Discovery Of New Sigma-2 Receptor Agonist Endowed With Antiproliferative Activity 367
Synthesis and biological evaluations of 4-alkyl-1-Arylpiperazine derivatives: SAR at 5-HT1A and 1 –Adrenoreceptor 360
Allosteric Inhibition of human Thymidylate Synthase. 359
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 352
1-(1,4-Dioxa-spiro[4.5]dec-2ylmethyl)-4-(2-methoxy-phenyl)-piperazine: SAR at alpha1 and 5-HT1A Receptors. 343
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 342
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma 341
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues 340
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 338
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors 335
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 331
Discovery of a new series of 5-HT1A receptor agonists 330
ANTICANCER DRUGS 329
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 317
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry 317
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 317
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 312
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 309
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain 304
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 302
DAT atypical inhibitors as novel antipsychotic drugs 300
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides 294
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 293
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 293
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 293
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach 293
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase 290
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays 283
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides 281
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones 276
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 276
Synthesis, biological evaluation and molecular modelling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 275
MALDI-TOF MS as a tool for rapid Identification of Low Protein Affinity Drug Fragments. 271
Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane 270
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 269
Derivati 1,3-diossanici come ligandi alpha1 adrenergici e 5-HT1A serotoninergici. 260
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents 258
Heteroarylphenoxyethyl amine as selective 5-HT1A receptor ligands: synthesis and structure-activity ralationship studies. 254
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at Adrenergic alpha1- and Serotonine 5-HT1A receptors 251
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 250
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 250
Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands. 247
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 247
Insights into the structure of the Human TAAR5 receptor: a computational study 245
Structure Activity Relationships at 5-HT1A receptors within a novel series of 4-alkyl-1-arylpiperazine derivatives 244
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 244
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 243
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 243
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity 236
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related abuse 234
Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry 231
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 228
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]dimethyl-amine 227
Merging disulphide bonds for drug design Interfering with a cancer key protein 227
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 226
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220 224
Investigation within a new series of heterocyclic biaryl piperazines acting at 5-HT1A serotoninergic receptors 221
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 220
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. 211
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands 204
Characterization of factor H-like molecules in Rainbow Trout 204
Ring opening effect at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel class of 1,3-Dioxolane-based ligands 202
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 201
Derivati 1,3-Diossanici come Antagonisti Muscarinici 201
Structure Activity Relationship at 5-HT1A receptors within a novel series of spiro-1,3-Dioxolane-based ligands 200
1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration 199
Synthesis and biological evaluation of Hsp90/HDAC6 dual inhibitors bearing a 2-amino-pyrrolopyrimidine and purine scaffold as potential anticancer drugs to treat prostate cancer 188
Relazioni struttura-attività in una nuova serie di ligandi alpha1-adrenergici e 5-HT1A serotoninergici a struttura 2,2-difenil-[1,3]diossolanica 186
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN 184
Risoluzione della miscela racemica del (±)-(2,2-difenil-[1,3]diossolan-4-ilmetil)-(2-fenossi-etil) ammina, potente antagonista alpha1 adrenergico, 183
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes 179
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 177
Nuova Serie di Ligandi Sigma a Struttura Piperazinica e Piperidinica 175
SAR at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel series of 1,3-Dioxolane-based ligands. 157
TB62, A POTENT 5-HT1A SEROTONERGIC FULL AGONIST, ENDOWED WITH DUAL ANTINOCICEPTIVE AND ANXIOLITIC/ANTIDEPRESSANT ACTIVITY 155
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol 153
Structure-Activity Relationships at alpha1-Adrenoceptor Subtypes within a New Series of 1,3-Dioxolane Derivatives 143
Monoclonal antibodies against mouse C3-fragments - a new repertoire of reagents targeting C3-mediated functions 140
The role of a newly-identified heterologous crosstalk between G-Protein coupled seven trasmembrane span receptors- Chemokine Receptor CXCR4 and Complement C3aR in Human hemato-lymphopoiesis and Innate Immunity 140
Sintesi e attivita' farmacologica di alcuni N-(1,3-diossolan-2-il-metil)-lattami 137
Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies 124
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status 119
Totale 29.942
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Categoria #
all - tutte 103.307
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 103.307
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.861 0 170 142 139 110 149 79 105 268 135 328 236
2022/20232.512 373 302 179 253 270 342 79 189 301 73 94 57
2023/20241.640 42 91 180 144 409 142 97 196 34 69 106 130
2024/20255.701 215 76 137 308 846 735 704 441 696 290 532 721
2025/20269.832 599 432 886 1.227 1.749 647 1.091 501 841 943 500 416
2026/2027281 267 14 0 0 0 0 0 0 0 0 0 0
Totale 29.962