FRANCHINI, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 13.100
EU - Europa 8.244
AS - Asia 6.184
SA - Sud America 921
AF - Africa 151
OC - Oceania 37
Continente sconosciuto - Info sul continente non disponibili 7
Totale 28.644
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Nazione #
US - Stati Uniti d'America 12.834
GB - Regno Unito 2.046
SG - Singapore 1.766
CN - Cina 1.642
IT - Italia 1.527
DE - Germania 1.292
SE - Svezia 1.010
VN - Vietnam 826
HK - Hong Kong 752
BR - Brasile 719
FI - Finlandia 564
RU - Federazione Russa 414
FR - Francia 316
UA - Ucraina 256
TR - Turchia 203
IN - India 201
KR - Corea 201
BE - Belgio 145
CA - Canada 139
BG - Bulgaria 120
NL - Olanda 112
PL - Polonia 102
IE - Irlanda 87
BD - Bangladesh 82
ID - Indonesia 81
MX - Messico 76
JP - Giappone 63
AR - Argentina 53
IQ - Iraq 51
RO - Romania 50
LT - Lituania 42
EC - Ecuador 40
ES - Italia 38
IR - Iran 32
AE - Emirati Arabi Uniti 31
ZA - Sudafrica 30
CO - Colombia 28
AT - Austria 26
NZ - Nuova Zelanda 26
PK - Pakistan 26
EG - Egitto 24
IL - Israele 24
SA - Arabia Saudita 24
CL - Cile 23
VE - Venezuela 22
TW - Taiwan 21
UZ - Uzbekistan 20
KE - Kenya 19
PH - Filippine 19
TH - Thailandia 18
CH - Svizzera 17
MA - Marocco 17
JO - Giordania 16
MY - Malesia 14
NO - Norvegia 13
PY - Paraguay 13
CZ - Repubblica Ceca 12
AU - Australia 11
KZ - Kazakistan 11
PE - Perù 11
TN - Tunisia 11
DZ - Algeria 10
PT - Portogallo 10
AZ - Azerbaigian 9
CI - Costa d'Avorio 8
CR - Costa Rica 8
JM - Giamaica 8
NG - Nigeria 7
SN - Senegal 7
BO - Bolivia 6
EU - Europa 6
NI - Nicaragua 6
AL - Albania 5
BH - Bahrain 5
DK - Danimarca 5
DO - Repubblica Dominicana 5
LB - Libano 5
LU - Lussemburgo 5
NP - Nepal 5
OM - Oman 5
PS - Palestinian Territory 5
BY - Bielorussia 4
GT - Guatemala 4
PR - Porto Rico 4
RS - Serbia 4
UY - Uruguay 4
BZ - Belize 3
CY - Cipro 3
ET - Etiopia 3
GR - Grecia 3
HU - Ungheria 3
LK - Sri Lanka 3
QA - Qatar 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
TZ - Tanzania 3
UG - Uganda 3
AM - Armenia 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
Totale 28.598
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Città #
Southend 1.253
Santa Clara 1.147
Singapore 1.088
Ashburn 1.080
Fairfield 813
Chandler 758
Hong Kong 708
Woodbridge 606
Ann Arbor 578
Munich 536
Hefei 505
Houston 495
Nyköping 463
Jacksonville 461
San Jose 437
Helsinki 430
Chicago 411
Dearborn 379
London 364
Seattle 364
Beijing 348
Wilmington 340
New York 333
Los Angeles 280
Cambridge 279
Ho Chi Minh City 253
Dallas 243
Modena 241
Berlin 211
Hanoi 192
Seoul 179
Council Bluffs 156
Brussels 141
Salt Lake City 128
Sofia 116
The Dalles 113
Frankfurt am Main 105
Milan 99
Princeton 99
Eugene 97
San Diego 90
Dublin 84
Izmir 81
Lauterbourg 80
Elk Grove Village 75
Moscow 74
Orem 68
Amsterdam 66
Tampa 66
Fremont 64
Des Moines 63
São Paulo 62
Buffalo 60
Shanghai 53
Tokyo 53
Bologna 51
Toronto 51
Redwood City 50
Warsaw 47
Jakarta 46
Da Nang 44
Bremen 42
Boardman 41
Yalova 41
Kraków 39
Mumbai 38
Mexico City 37
Shenzhen 35
Turku 33
Grafing 32
Phoenix 31
Sterling 31
Boston 30
Haiphong 30
Verona 27
Auckland 26
Montreal 26
Norwalk 26
Philadelphia 26
Rome 26
Chennai 25
Lancaster 25
Atlanta 24
Columbus 23
Denver 23
Brooklyn 22
Guangzhou 22
Hillsboro 22
Jyväskylä 22
Milwaukee 22
Sochi 22
West Jordan 22
Augusta 21
Parma 21
Saint Petersburg 21
Falls Church 20
Kent 20
Baghdad 19
Paris 19
Reggio Emilia 19
Totale 19.208
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Nome #
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands 929
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 795
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors 746
(2,2-difenil-[1,3]-diossolan-4ilmetil)-(3-fenil-propil)-ammina: nuovo agonista parziale del recettore serotoninergico 5-HT1A 639
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 568
1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists 507
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors 482
1,3-dioxolane-based ligands in the search for alpha1-adrenergic antagonists. 447
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist 440
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study 438
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression 425
Synthesis and pharmacological evaluation of 1-benzylpiperazine and 4-benzylpiperidine as potent sigma ligands. 419
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain. 403
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury 392
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues 388
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 387
Cloning and purification of the Rainbow Trout fifth component of complement (C5). 370
Discovery Of New Sigma-2 Receptor Agonist Endowed With Antiproliferative Activity 365
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 357
Synthesis and biological evaluations of 4-alkyl-1-Arylpiperazine derivatives: SAR at 5-HT1A and 1 –Adrenoreceptor 353
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 341
Allosteric Inhibition of human Thymidylate Synthase. 340
1-(1,4-Dioxa-spiro[4.5]dec-2ylmethyl)-4-(2-methoxy-phenyl)-piperazine: SAR at alpha1 and 5-HT1A Receptors. 337
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 337
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues 332
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma 330
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors 328
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 327
ANTICANCER DRUGS 322
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 321
Discovery of a new series of 5-HT1A receptor agonists 320
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 312
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry 311
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 310
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 307
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain 300
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 293
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 293
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides 290
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 284
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides 276
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase 276
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays 274
DAT atypical inhibitors as novel antipsychotic drugs 274
MALDI-TOF MS as a tool for rapid Identification of Low Protein Affinity Drug Fragments. 269
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones 268
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach 268
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 266
Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane 265
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 265
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 262
Synthesis, biological evaluation and molecular modelling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 259
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 259
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents 253
Heteroarylphenoxyethyl amine as selective 5-HT1A receptor ligands: synthesis and structure-activity ralationship studies. 251
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 246
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 244
Derivati 1,3-diossanici come ligandi alpha1 adrenergici e 5-HT1A serotoninergici. 241
Structure Activity Relationships at 5-HT1A receptors within a novel series of 4-alkyl-1-arylpiperazine derivatives 240
Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands. 240
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 235
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity 235
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 230
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at Adrenergic alpha1- and Serotonine 5-HT1A receptors 229
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 229
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 227
Insights into the structure of the Human TAAR5 receptor: a computational study 226
Merging disulphide bonds for drug design Interfering with a cancer key protein 224
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]dimethyl-amine 222
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 221
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 220
Investigation within a new series of heterocyclic biaryl piperazines acting at 5-HT1A serotoninergic receptors 218
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220 216
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 212
Characterization of factor H-like molecules in Rainbow Trout 203
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related abuse 201
Structure Activity Relationship at 5-HT1A receptors within a novel series of spiro-1,3-Dioxolane-based ligands 197
Derivati 1,3-Diossanici come Antagonisti Muscarinici 197
Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry 195
Ring opening effect at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel class of 1,3-Dioxolane-based ligands 194
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. 192
Relazioni struttura-attività in una nuova serie di ligandi alpha1-adrenergici e 5-HT1A serotoninergici a struttura 2,2-difenil-[1,3]diossolanica 184
Risoluzione della miscela racemica del (±)-(2,2-difenil-[1,3]diossolan-4-ilmetil)-(2-fenossi-etil) ammina, potente antagonista alpha1 adrenergico, 181
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 180
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN 179
Synthesis and biological evaluation of Hsp90/HDAC6 dual inhibitors bearing a 2-amino-pyrrolopyrimidine and purine scaffold as potential anticancer drugs to treat prostate cancer 178
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes 177
1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration 174
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 172
Nuova Serie di Ligandi Sigma a Struttura Piperazinica e Piperidinica 171
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands 160
SAR at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel series of 1,3-Dioxolane-based ligands. 150
Structure-Activity Relationships at alpha1-Adrenoceptor Subtypes within a New Series of 1,3-Dioxolane Derivatives 141
Monoclonal antibodies against mouse C3-fragments - a new repertoire of reagents targeting C3-mediated functions 138
The role of a newly-identified heterologous crosstalk between G-Protein coupled seven trasmembrane span receptors- Chemokine Receptor CXCR4 and Complement C3aR in Human hemato-lymphopoiesis and Innate Immunity 137
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol 135
Sintesi e attivita' farmacologica di alcuni N-(1,3-diossolan-2-il-metil)-lattami 135
TB62, A POTENT 5-HT1A SEROTONERGIC FULL AGONIST, ENDOWED WITH DUAL ANTINOCICEPTIVE AND ANXIOLITIC/ANTIDEPRESSANT ACTIVITY 128
Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies 117
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status 116
Totale 28.857
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Categoria #
all - tutte 96.629
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 96.629
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021285 0 0 0 0 0 0 0 0 0 0 186 99
2021/20221.972 111 170 142 139 110 149 79 105 268 135 328 236
2022/20232.512 373 302 179 253 270 342 79 189 301 73 94 57
2023/20241.640 42 91 180 144 409 142 97 196 34 69 106 130
2024/20255.701 215 76 137 308 846 735 704 441 696 290 532 721
2025/20269.008 599 432 886 1.227 1.749 647 1.091 501 841 943 92 0
Totale 28.857