FRANCHINI, Silvia
 Distribuzione geografica
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Continente #
NA - Nord America 16.059
EU - Europa 8.571
AS - Asia 6.460
SA - Sud America 962
Continente sconosciuto - Info sul continente non disponibili 232
AF - Africa 165
OC - Oceania 37
Totale 32.486
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Nazione #
US - Stati Uniti d'America 15.589
GB - Regno Unito 2.066
SG - Singapore 1.793
IT - Italia 1.777
CN - Cina 1.665
DE - Germania 1.294
SE - Svezia 1.016
VN - Vietnam 828
HK - Hong Kong 757
BR - Brasile 744
FI - Finlandia 564
RU - Federazione Russa 433
FR - Francia 317
UA - Ucraina 258
BD - Bangladesh 255
CA - Canada 240
KR - Corea 215
TR - Turchia 206
IN - India 205
BE - Belgio 145
BG - Bulgaria 120
NL - Olanda 118
PL - Polonia 105
IE - Irlanda 90
ID - Indonesia 82
MX - Messico 79
JP - Giappone 67
AR - Argentina 54
IQ - Iraq 51
RO - Romania 50
LT - Lituania 44
EC - Ecuador 42
ES - Italia 42
IL - Israele 36
CO - Colombia 35
AE - Emirati Arabi Uniti 32
IR - Iran 32
ZA - Sudafrica 30
PK - Pakistan 27
AT - Austria 26
CR - Costa Rica 26
NZ - Nuova Zelanda 26
SA - Arabia Saudita 25
CL - Cile 24
EG - Egitto 24
VE - Venezuela 24
TW - Taiwan 23
KE - Kenya 20
PH - Filippine 20
UZ - Uzbekistan 20
NI - Nicaragua 18
TH - Thailandia 18
CH - Svizzera 17
JM - Giamaica 17
JO - Giordania 17
MA - Marocco 17
SC - Seychelles 15
MY - Malesia 14
PY - Paraguay 14
TT - Trinidad e Tobago 14
GT - Guatemala 13
HN - Honduras 13
NO - Norvegia 13
PR - Porto Rico 13
CZ - Repubblica Ceca 12
KZ - Kazakistan 12
AU - Australia 11
CW - ???statistics.table.value.countryCode.CW??? 11
PE - Perù 11
TN - Tunisia 11
DZ - Algeria 10
GP - Guadalupe 10
PT - Portogallo 10
AZ - Azerbaigian 9
CI - Costa d'Avorio 8
DK - Danimarca 8
SV - El Salvador 8
NG - Nigeria 7
SN - Senegal 7
BO - Bolivia 6
DO - Repubblica Dominicana 6
EU - Europa 6
AL - Albania 5
BH - Bahrain 5
EE - Estonia 5
LB - Libano 5
LU - Lussemburgo 5
NP - Nepal 5
OM - Oman 5
PS - Palestinian Territory 5
UY - Uruguay 5
BY - Bielorussia 4
GR - Grecia 4
HU - Ungheria 4
RS - Serbia 4
BZ - Belize 3
CY - Cipro 3
ET - Etiopia 3
GY - Guiana 3
LK - Sri Lanka 3
Totale 32.213
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Città #
Ashburn 1.848
Southend 1.253
Santa Clara 1.207
Singapore 1.097
Fairfield 813
Chandler 758
Hong Kong 712
San Jose 703
Woodbridge 606
Ann Arbor 578
Munich 536
Council Bluffs 524
Hefei 505
Houston 500
Nyköping 463
Jacksonville 462
Helsinki 430
Chicago 427
New York 394
Dearborn 379
Seattle 373
London 367
Beijing 350
Wilmington 342
Los Angeles 336
Cambridge 284
Dallas 269
Ho Chi Minh City 254
Modena 242
Berlin 211
Hanoi 193
Seoul 179
Milan 142
Brussels 141
Salt Lake City 130
Sofia 116
The Dalles 114
Frankfurt am Main 105
Princeton 103
Eugene 97
San Diego 90
Buffalo 87
Dublin 84
Izmir 81
Lauterbourg 80
Elk Grove Village 78
São Paulo 76
Toronto 75
Moscow 74
Columbus 73
Orem 70
Tampa 69
Amsterdam 66
Fremont 66
Des Moines 64
Phoenix 57
Tokyo 57
Shanghai 56
Bologna 55
Rome 51
Redwood City 50
Washington 50
Boardman 49
Warsaw 47
Jakarta 46
Da Nang 44
Bremen 42
Yalova 41
Kraków 39
Montreal 39
Mumbai 39
Mexico City 38
Denver 37
Shenzhen 35
Atlanta 33
Boston 33
Philadelphia 33
Turku 33
Grafing 32
Sterling 31
Brooklyn 30
Haiphong 30
Verona 29
Naples 28
Hillsboro 27
Norwalk 27
Auckland 26
Chennai 26
Milwaukee 26
Lancaster 25
Augusta 24
San Francisco 24
Guangzhou 22
Jyväskylä 22
Parma 22
Sochi 22
West Jordan 22
Miami 21
Reggio Emilia 21
Saint Petersburg 21
Totale 21.238
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Nome #
1,2,4-Benzothiadiazine derivatives as alpha(1) and 5-HT1A receptor ligands 1.017
1,3-Diossolani e analoghi aperti come nuovi ligandi per il recettore Sigma 843
1,3-Dioxolane-Based Ligands Incorporating a Lactam or Imide moiety: Structure-Affinity/Activity Relationship at alpha1–Adrenoceptor subtypes and at 5-HT1A Receptors 775
(2,2-difenil-[1,3]-diossolan-4ilmetil)-(3-fenil-propil)-ammina: nuovo agonista parziale del recettore serotoninergico 5-HT1A 665
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity 606
1,3-Dioxolane-Based Ligands as a Novel Class of Alpha1-Adrenoceptor Antagonists 553
1,3-Dioxolane-Based Ligands as Rigid Analogues ofNaftopidil: Structure–Affinity/Activity Relationships at a1and 5-HT1A Receptors 536
1,3-dioxolane-based ligands in the search for alpha1-adrenergic antagonists. 470
(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenylpropyl)-amine: a Potent and Selective 5-HT1A Receptor Agonist 466
Synthesis and pharmacological evaluation of 1-benzylpiperazine and 4-benzylpiperidine as potent sigma ligands. 464
Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study 459
Discovery of a new 5-HT1A receptor agonist, acting ‘in vivo’ in a rat model of anxiety and depression 452
Development, Validation and Application of an LC-MS/MS Bioanalytical Method for the Quantification of GF449, A Novel 5-HT1A Agonist, in Rat Plasma and Brain. 441
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 431
C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury 416
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists 416
A New and Versatile Synthesis of 1,3-Dioxan-5-yl-pyrimidine and Purine Nucleoside Analogues 415
Allosteric Inhibition of human Thymidylate Synthase. 400
Synthesis and biological evaluations of 4-alkyl-1-Arylpiperazine derivatives: SAR at 5-HT1A and 1 –Adrenoreceptor 399
Discovery Of New Sigma-2 Receptor Agonist Endowed With Antiproliferative Activity 391
NUOVE MOLECOLE, PER USO COME AGENTI ANTITUMORALI 389
Cloning and purification of the Rainbow Trout fifth component of complement (C5). 386
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 375
Diastereoselective Synthesis of (1,3-Dioxan-4-yl)pyrimidine and Purin Nucleoside Analogues 370
Further insights into the pharmacology of the human Trace Amine-Associated Receptors: discovery of novel ligands for TAAR1 by a virtual screening approach 363
1-(1,4-Dioxa-spiro[4.5]dec-2ylmethyl)-4-(2-methoxy-phenyl)-piperazine: SAR at alpha1 and 5-HT1A Receptors. 359
Synthesis and structure-activity relationships of 1-aralkyl-4- benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent σ ligands 358
Structure-Activity Relationship within a new series of σ1 and σ2 receptor ligands: identification of a novel σ2R agonist (BS148) with selective toxicity against metastatic melanoma 358
Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 356
Synthesis and antimuscarinic activity of some N-(4-dimethylaminomethyl-2-phenyl-1,3)dioxolan-2-ylmethyl)lactam methiodides 356
Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors 355
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding 355
Discovery of a new series of 5-HT1A receptor agonists 354
ANTICANCER DRUGS 347
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 339
Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry 334
Alternative strategies in medicinal chemistry to face drug resistance in anticancer therapy. 330
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase. 329
Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer 329
Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs) 326
BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting 324
DAT atypical inhibitors as novel antipsychotic drugs 318
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 317
Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT 1A receptor agonists for CNS disorders and neuropathic pain 316
Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides 314
Cell-cycle Inhibition by Helicobacter pylori L-Asparaginase 313
Synthesis, biological evaluation and molecular modelling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists 307
MALDI-TOF MS as a tool for rapid Identification of Low Protein Affinity Drug Fragments. 299
Exhaustive CoMFA and CoMSIA analyses around different chemical entities: A ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands 299
Synthesis and Antimuscarinic Activity of Some Ether- and Thioether-Bearing 1,3-dioxolanes and Related Sulfoxides and Sulfones 297
Novel monoclonal antibodies against mouse C3 interfering with complement activation: Description of fine specificity and applications to various immunoassays 295
Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane 290
Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline 289
Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents 285
Synthesis and antimuscarinic activity of derivatives of 2-substituted-1,3-dioxolanes 282
Derivati 1,3-diossanici come ligandi alpha1 adrenergici e 5-HT1A serotoninergici. 280
Synthesis, Biological Evaluation and Docking Studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at Adrenergic alpha1- and Serotonine 5-HT1A receptors 279
Insights into the structure of the Human TAAR5 receptor: a computational study 279
Unusual Targeting of the human Thymidylate synthase interface: a tethering approach with mass-spectrometric detection. 275
Heteroarylphenoxyethyl amine as selective 5-HT1A receptor ligands: synthesis and structure-activity ralationship studies. 273
Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands. 269
Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer 267
Structure Activity Relationships at 5-HT1A receptors within a novel series of 4-alkyl-1-arylpiperazine derivatives 267
Ring opening effect at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel class of 1,3-Dioxolane-based ligands 265
Fragment Based Discovery of Thymidylate Synthase Dimeric Interface Inhibitors Through Mass Spectrometry. Invited lecture to the Fragment Based Lead Discovery track. 264
Constrained 1,4-dialkylpiperazines as monoamine transporters inhibitors for cocaine-related abuse 262
Effect of the rigidification of propranolol, a mixed β-adrenoceptor and 5-HT1AR antagonist 260
Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents 259
Effect of aromatic substitution on antimuscarinic activity of 2-phenyl-2-cyclohexyl-4-[(dimethylamino)methyl]-1,3-dioxolanes 255
Investigation within a new series of heterocyclic biaryl piperazines acting at 5-HT1A serotoninergic receptors 253
Identification of a Potent and Selective 5-HT1AReceptor Agonist with In Vitro and In Vivo Antinociceptive Activity 253
Insights into the structure and pharmacology of Trace Amine-Associated Receptor 1 (TAAR1), a new target for medicinal chemistry 252
Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]dimethyl-amine 244
Second Joint Italian-Swiss Meeting on Medicinal Chemistry , Italy, Modena 19-20 February 2005. 244
Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group 243
Merging disulphide bonds for drug design Interfering with a cancer key protein 242
Kinetic Analysis of the Interactions of Complement Receptor 2(CR2, CD21) with Its Ligands C3d, iC3b, and the EBVGlycoprotein gp350/220 238
Multitarget 1,4-Dioxane Compounds Combining Favorable D 2 -like and 5-HT 1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia 238
1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute Configuration 231
Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands 230
A novel role of complement: mice deficient in the fifth componenet of complement (C5) exhibit impaired liver regeneration. 228
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents 221
Characterization of factor H-like molecules in Rainbow Trout 218
Derivati 1,3-Diossanici come Antagonisti Muscarinici 215
Structure Activity Relationship at 5-HT1A receptors within a novel series of spiro-1,3-Dioxolane-based ligands 213
Synthesis and biological evaluation of Hsp90/HDAC6 dual inhibitors bearing a 2-amino-pyrrolopyrimidine and purine scaffold as potential anticancer drugs to treat prostate cancer 209
Risoluzione della miscela racemica del (±)-(2,2-difenil-[1,3]diossolan-4-ilmetil)-(2-fenossi-etil) ammina, potente antagonista alpha1 adrenergico, 204
Relazioni struttura-attività in una nuova serie di ligandi alpha1-adrenergici e 5-HT1A serotoninergici a struttura 2,2-difenil-[1,3]diossolanica 201
IDENTIFICATION OF POTENT 1,3-DIOXOLANE-BASED 5-HT1A RECEPTOR AGONISTS FOR THE TREATMENTS OF CNS DISORDERS AND PAIN 195
Nuova Serie di Ligandi Sigma a Struttura Piperazinica e Piperidinica 193
Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors 192
Monoclonal antibodies against mouse C3-fragments - a new repertoire of reagents targeting C3-mediated functions 185
The role of a newly-identified heterologous crosstalk between G-Protein coupled seven trasmembrane span receptors- Chemokine Receptor CXCR4 and Complement C3aR in Human hemato-lymphopoiesis and Innate Immunity 182
TB62, A POTENT 5-HT1A SEROTONERGIC FULL AGONIST, ENDOWED WITH DUAL ANTINOCICEPTIVE AND ANXIOLITIC/ANTIDEPRESSANT ACTIVITY 178
Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol 178
SAR at alpha1-adrenoceptor subtypes and 5-HT1A receptors within a novel series of 1,3-Dioxolane-based ligands. 173
Structure-Activity Relationships at alpha1-Adrenoceptor Subtypes within a New Series of 1,3-Dioxolane Derivatives 163
Sintesi e attivita' farmacologica di alcuni N-(1,3-diossolan-2-il-metil)-lattami 153
Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD studies 145
Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status 135
Totale 32.431
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Categoria #
all - tutte 112.105
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 112.105
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.410 0 0 0 0 110 149 79 105 268 135 328 236
2022/20232.512 373 302 179 253 270 342 79 189 301 73 94 57
2023/20241.640 42 91 180 144 409 142 97 196 34 69 106 130
2024/20255.701 215 76 137 308 846 735 704 441 696 290 532 721
2025/20269.832 599 432 886 1.227 1.749 647 1.091 501 841 943 500 416
2026/20272.805 267 495 779 1.052 212 0 0 0 0 0 0 0
Totale 32.486