TAGLIAZUCCHI, LORENZO
 Distribuzione geografica
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Continente #
NA - Nord America 4.365
AS - Asia 3.986
EU - Europa 3.157
SA - Sud America 446
AF - Africa 93
Continente sconosciuto - Info sul continente non disponibili 76
OC - Oceania 14
Totale 12.137
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Nazione #
US - Stati Uniti d'America 4.195
IT - Italia 1.349
CN - Cina 1.265
SG - Singapore 1.157
DE - Germania 432
VN - Vietnam 387
HK - Hong Kong 359
BR - Brasile 328
SE - Svezia 276
GB - Regno Unito 240
KR - Corea 215
RU - Federazione Russa 155
FR - Francia 139
FI - Finlandia 113
BD - Bangladesh 108
ID - Indonesia 99
CA - Canada 93
IN - India 90
ES - Italia 66
NL - Olanda 62
JP - Giappone 54
LT - Lituania 45
IQ - Iraq 43
CH - Svizzera 42
IE - Irlanda 37
PL - Polonia 37
AR - Argentina 35
MX - Messico 29
BE - Belgio 28
ZA - Sudafrica 28
PK - Pakistan 22
TR - Turchia 22
AT - Austria 20
CL - Cile 19
UA - Ucraina 19
MY - Malesia 18
EC - Ecuador 17
UZ - Uzbekistan 17
IR - Iran 15
SA - Arabia Saudita 15
PH - Filippine 14
MA - Marocco 13
TW - Taiwan 13
CZ - Repubblica Ceca 12
GR - Grecia 12
PY - Paraguay 12
VE - Venezuela 12
AE - Emirati Arabi Uniti 11
BG - Bulgaria 11
CO - Colombia 11
KE - Kenya 11
TN - Tunisia 11
AU - Australia 10
CR - Costa Rica 9
JM - Giamaica 9
HN - Honduras 8
TH - Thailandia 8
ET - Etiopia 7
GT - Guatemala 7
NP - Nepal 7
RO - Romania 7
DK - Danimarca 6
JO - Giordania 6
LI - Liechtenstein 6
NO - Norvegia 6
RS - Serbia 6
UY - Uruguay 6
BY - Bielorussia 5
DZ - Algeria 5
EG - Egitto 5
KZ - Kazakistan 5
MO - Macao, regione amministrativa speciale della Cina 5
PE - Perù 5
AL - Albania 4
AZ - Azerbaigian 4
EE - Estonia 4
IL - Israele 4
LV - Lettonia 4
NZ - Nuova Zelanda 4
PT - Portogallo 4
BH - Bahrain 3
GE - Georgia 3
HU - Ungheria 3
LB - Libano 3
LK - Sri Lanka 3
MD - Moldavia 3
NI - Nicaragua 3
PR - Porto Rico 3
SN - Senegal 3
SV - El Salvador 3
CW - ???statistics.table.value.countryCode.CW??? 2
DO - Repubblica Dominicana 2
GH - Ghana 2
KG - Kirghizistan 2
LU - Lussemburgo 2
NG - Nigeria 2
PS - Palestinian Territory 2
SC - Seychelles 2
TT - Trinidad e Tobago 2
AF - Afghanistan, Repubblica islamica di 1
Totale 12.048
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Città #
Singapore 716
Santa Clara 683
Hefei 613
San Jose 523
Ashburn 506
Hong Kong 345
Council Bluffs 332
Modena 198
Seoul 196
Frankfurt am Main 167
Ho Chi Minh City 141
London 136
Chandler 135
New York 134
Los Angeles 121
Bologna 120
Nyköping 113
Beijing 111
Jakarta 81
Hanoi 80
Milan 76
The Dalles 76
Helsinki 75
Parma 62
Munich 61
Reggio Emilia 60
Boardman 57
Chicago 51
Dallas 50
Moscow 47
Shanghai 45
Buffalo 43
Lauterbourg 43
Orem 39
São Paulo 37
Fairfield 36
Kent 33
Dublin 30
Warsaw 30
Rome 29
Houston 28
Denver 26
Seattle 25
Tokyo 25
Toronto 25
Amsterdam 24
Formigine 24
Lappeenranta 23
Phoenix 22
Madrid 21
Zurich 21
Atlanta 20
Princeton 20
Turin 20
Padova 19
Da Nang 18
Nuremberg 18
San Diego 18
Wilmington 18
Piacenza 17
Salt Lake City 17
Stockholm 17
Washington 17
Chennai 16
Boston 15
Leuven 15
Naples 15
Paris 15
Decatur 14
Sassuolo 14
Tashkent 14
Barcelona 13
Ferrara 13
Johannesburg 13
Manchester 13
Brooklyn 12
Cambridge 12
Düsseldorf 12
Hangzhou 12
Mexico City 12
Montreal 12
Osnabrück 12
Padua 12
Perugia 12
Portsmouth 12
Ravenna 12
Santiago 12
Vienna 12
Baghdad 11
Guangzhou 11
Ottawa 11
Poplar 11
Rio de Janeiro 11
Brussels 10
Charlotte 10
Haiphong 10
Hamburg 10
Nairobi 10
Redondo Beach 10
Tehran 10
Totale 7.365
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Nome #
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 325
Designing selective Cys-ligands to unpair the binding of the Human Transcription Enhancer Associated Domain 4 (hTEAD-4) with its modulators to halt cancer cell growth 321
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 313
Exploiting Forster Resonance Energy Transfer (FRET) in the characterization of YAP:TEAD complex disruption 288
design, synthesis and biological evaluation of novel YAP:TEAD complex disruptors for thetreatment of colorectal cancer 259
Development of a novel class of YAP:TEAD interface-3 molecular disruptors to treat colorectal carcinoma 255
Repurposing the trypanosomatidic gsk kinetobox for the inhibition of parasitic pteridine and dihydrofolate reductases 255
A toolbox of biophysical and analytical assays helps to confirm the activity of novel hTS dimer disrupters (Ddis) with anticancer properties 254
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase 250
LC-MS/MS Helps Characterizing THP-1 Cells Proteome After Infection with Drug Resistant Leishmania Strains 247
Identification of a Quinone Derivative as a YAP/TEAD Activity Modulator from a Repurposing Library 243
A dual-Omics approach to identify the modulated proteins/genes in THP-1 cells infected with different drug resistant L. infantum clinical isolates. 242
Serum Mass Spectrometry Proteomics and Protein Set Identification in Response to FOLFOX-4 in Drug-Resistant Ovarian Carcinoma 242
Applying optical tweezers technology to reveal Thymidylate Synthase interactions with its consensus mRNA 240
LC-MS serum proteomics reveals a panel of proteins prognostic of positive responsiveness to bevacizumab therapy in late-stages ovarian cancer patients 237
Lead optimization of human thymidylate synthase dimer disrupters: from computational studies to evaluation of their biological profiles 234
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents 232
Targeting the dimer-monomer equilibrium of thymidylate synthase, to accelerate protein degradation and cancer cell growth inhibition 225
Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation 225
Advances in the set-up of a fluorescence- anisotropy assay for the search of novel inhibitors of the tead-4 complexes 225
Current Treatments to Control African Trypanosomiasis and One Health Perspective 225
Exploring thymidylate synthase mRNA binding site 1 and human TS protein interaction with optical tweezers and bicistronic expression assay 222
Coupling a microwave-assisted process with HPLC-ELSD for the extraction, purification and analysis of bioactive policosanols from beeswax 221
Structural bases for the synergistic inhibition of human thymidylate synthase and ovarian cancer cell growth by drug combinations 212
Lead-optimization process and characterization of the dissociative effect applied to new dimer disrupters of human Thymidylate Synthase 206
Precision medicine through proteomics studies in drug resistant colorectal cancer 206
Integrating MS proteomics in the Medicinal Chemistry pipeline as powerful tool to overcome drug resistance issues in colorectal cancer 205
UHPLC-MS/MS screening of the hTEAD surface for the identification of novel allosteric inhibitors with anticancer activity 202
Development of a sensitive biochemical tool to assess the expression levels of recombinant ectopic proteins in in vitro engineered cellular systems 201
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents 199
Characterization and Valorization of the Agricultural Waste Obtained from Lavandula Steam Distillation for Its Reuse in the Food and Pharmaceutical Fields 199
integrazione della proteomica mediante spettrometria di massa nel processo di Drug Discovery come strumento innovativo per superare la farmacoresistenza 198
Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance Leishmania infantum Clinical Isolates 197
EXPLOITING THE OPTICAL TWEEZER, A SINGLE MOLECULE TECHNOLOGY, TO REVEAL THYMIDYLATE SYNTHASE INTERACTIONS WITH ITS CONSENSUS mRNA 196
Exploiting the Optical Tweezer technology to reveal thymidylate synthase interactions with its consensus mRNA 196
Drug discovery of pyrazolo-piperidinone inhibitors targeting YAP:TEAD interaction and development of a fluorescence anisotropy assay for high-throughput screening 194
Advancing sustainable drug development: comparative preclinical study of H80 and Miltefosine using imaging and proteomics 193
Expression, purification, and characterization of Transcriptional Enhancer Associated Domain (hTEAD4), a promising target for anticancer agents 193
Cellular uptake and metabolic degradation of a conjugate of folic acid with an anticancer peptide targeting the human Thymidylate synthase enzyme 191
Antitarget, Anti-SARS-CoV-2 Leads, Drugs, and the Drug Discovery-Genetics Alliance Perspective 189
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells 188
Insights into host-target interaction from the proteome modulation analysis through untargeted LC-MS/MS Proteomics of drug resistant L infantum-THP1 infected cells 185
Deciphering Host–Parasite Interplay in Leishmania Infection through a One Health View of Proteomics Studies on Drug Resistance 181
Investigating the mechanism of action of the antiparasitic agent H80 through imaging techniques 181
Leveraging proteomic, bioinformatic and ecotoxicology models to select new targets overcoming L. Infantum drug resistent 178
Discovery of guanidino-containing benzimidazoles as novel antifolates for Trypanosomiasis 178
LC-MS/MS proteomics for the rapid and selective screening of drug resistances in Leishmania infantum clinical isolates 176
One Health Approach in Drug Discovery for Leishmaniasis by Targeting Calpain cys-protease. 175
Optimization of chemical-biological tools for characterizing the activity of dissociative inhibitor of human thymidylate synthase 174
MS Proteomics And Biochemical Characterization Of Thymidylate Synthase Dimer Destabilizer E7 To Halt Colorectal Carcinoma 164
Development of guanidino-containing benzimidazoles as novel folate enzymes inhibitors for the treatment of Human African Trypanosomiasis 154
Promoting A Sustainable Medicinal Chemistry Approach With The Cost Action CA21111 - One Health Drugs Against Parasitic Vector Borne Diseases In Europe And Beyond 142
Leveraging proteomics, bioinformatics, and ecotoxicology models to select new targets overcoming L infantum drug resistance. 139
Targeting of the Cysteines Surface domain of the Transcriptional Enhancer Associate Domain (TEAD) for anticancer drug discovery 139
Structural insight into YAP-TEAD4 protein-protein interactions as target for cancer treatment 136
Proteomic contribution to the omic path for the identification of novel drugs overcoming resistance in Leishmaniasis. 126
Preclinical investigation of H80 compared to miltefosine: imaging and proteomics for sustainable drug development 117
Development of a fluorescent anisotropy displacement assay for the optimization of YAP:TEAD molecular disrupters with anticancer activity 112
IDENTIFICATION OF PYRAZOLO-PIPERIDINONE DERIVATIVES TARGETING YAP-TEAD INTERFACE 3 AS ANTICANCER AGENTS THROUGH INTEGRATED VIRTUAL SCREENING AND MASS SPECTROMETRY PROTEOMICS 111
A stretch-responsive fibroblast program promotes epidermal stem cell self-renewal during skin expansion 19
Targeting the YAP:TEAD domain through fluorescence-anisotropy displacement assay 5
Totale 12.137
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Categoria #
all - tutte 47.938
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.938
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022329 0 0 0 2 2 47 18 32 50 41 85 52
2022/2023859 87 69 30 61 76 71 85 99 122 32 73 54
2023/20241.302 62 78 87 73 321 86 84 104 37 40 181 149
2024/20253.270 112 46 129 199 556 465 211 245 329 143 409 426
2025/20265.116 473 319 445 613 638 285 674 247 447 500 311 164
2026/20271.167 115 233 355 464 0 0 0 0 0 0 0 0
Totale 12.137