Structure−Dynamics−Property Relationship Reveals the Origin of Porous Integrity in Imine-Linked Covalent Organic Frameworks

Molecular flexibility encoded in low-frequency lattice dynamics is increasingly recognized as a key determinant of the properties of porous materials, particularly metal–organic frameworks, but remains largely unexplored in covalent organic frameworks (COFs). Here, we establish a structure–dynamics–property relationship for chemically related COFs by combining three-dimensional electron diffraction, low-frequency vibrational spectroscopy, and first-principles calculations. Using 3D electron d...

Toward a Patient-Specific Model of Protein-Bound Uremic Toxin Kinetics during Online Haemodiafiltration

Protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS), are poorly removed by conventional hemodialysis because of their strong affinity for plasma proteins, which reduces the effective diffusive driving force across the dialyzer membrane. Existing mechanistic models of PBUTs kinetics during hemodialysis rely on population-averaged parameters, thereby limiting their predictive capability at the individual patient level. In this work, a patient-specific ex...

Calibration and Enhancement of Analytical IR-Drop Model for Resistive Crossbar Arrays

Capitoli "La pianura modenese", "La Prima zona partigiana", "La Seconda zona partigiana", "La Terza zona partigiana", "La Settima zona partigiana"