In an era of increasing antimicrobial resistance (AMR), we present a targeted strategy of molecular enhancement through adjuvants to restore the activity of existing antibiotics. By combining oxacillin with hydroxyl-benzoxaborole derivatives (HBO-d), we successfully restored its efficacy against methicillin-resistant Staphylococcus aureus (MRSA). Boron-containing compounds thus represent a promising scaffold for the development of adjuvants capable of overcoming β-lactam resistance in MRSA, offering new opportunities to enhance the effectiveness of existing antibiotics and extend their clinical utility against multidrug-resistant pathogens
New life for old drugs: hydroxyl-benzoxaborole derivatives resensitise MRSA to oxacillin / Bellio, Pierangelo; Fagnani, Lorenza; Eleonora, Scarsella; Tondi, Donatella; Celenza, Giuseppe. - (2025). ( 53° Congresso Nazionale Società Italiana di Microbiologia Catania 19-22 Settembre 2025).
New life for old drugs: hydroxyl-benzoxaborole derivatives resensitise MRSA to oxacillin
Donatella TondiInvestigation
;
2025
Abstract
In an era of increasing antimicrobial resistance (AMR), we present a targeted strategy of molecular enhancement through adjuvants to restore the activity of existing antibiotics. By combining oxacillin with hydroxyl-benzoxaborole derivatives (HBO-d), we successfully restored its efficacy against methicillin-resistant Staphylococcus aureus (MRSA). Boron-containing compounds thus represent a promising scaffold for the development of adjuvants capable of overcoming β-lactam resistance in MRSA, offering new opportunities to enhance the effectiveness of existing antibiotics and extend their clinical utility against multidrug-resistant pathogens
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