Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.
VDAC2 enforces a mitochondrial checkpoint to cancer immunity / Cosentino, K.; Verduijn, J.; Galluzzi, L.. - In: NATURE IMMUNOLOGY. - ISSN 1529-2908. - 26:6(2025), pp. 808-809. [10.1038/s41590-025-02171-1]
VDAC2 enforces a mitochondrial checkpoint to cancer immunity
Cosentino K.
;Galluzzi L.
2025
Abstract
Mitochondrial integrity controls cellular and immunological homeostasis in various pathophysiological settings. Recent findings suggest that VDAC2 antagonizes the ability of IFNγ to drive mitochondrial permeabilization in malignant cells by inhibiting BAK, thus promoting cell survival and immunoevasion.
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